Effect of Zinc Supplementation on the Serum Metabolites Profile at the Early Stage of Breast Cancer in Rats

被引：18

作者：

Bobrowska-Korczak, Barbara ^{[1
]}

Gatarek, Paulina ^{[2
]}

Skrajnowska, Dorota ^{[1
]}

Bielecki, Wojciech ^{[3
]}

Wyrebiak, Rafal ^{[4
]}

Kovalczuk, Tomas ^{[5
]}

Wrzesien, Robert ^{[6
]}

Kaluzna-Czaplinska, Joanna ^{[2
]}

机构：

[1] Med Univ Warsaw, Fac Pharm, Dept Bromatol, Lab Med Div, Stefana Banacha 1, PL-02097 Warsaw, Poland

[2] Lodz Univ Technol, Inst Gen & Ecol Chem, Dept Chem, Stefana Zeromskiego 116, PL-90924 Lodz, Poland

[3] Warsaw Univ Live Sci, Fac Vet Med, Dept Pathol & Vet Diagnost, Nowoursynowska 159c, PL-02787 Warsaw, Poland

[4] Med Univ Warsaw, Dept Biomat Chem Analyt Chem & Biomat, Fac Pharm, Lab Med Div, Stefana Banacha 1, PL-02097 Warsaw, Poland

[5] LECO Instrumente Plzen, Plaska 66, Plzen 32300, Czech Republic

[6] Med Univ Warsaw, Cent Lab Expt Anim, Stefana Banacha 1a, PL-02091 Warsaw, Poland

来源：

NUTRIENTS | 2020年 / 12卷 / 11期

关键词：

breast cancer; zinc nanoparticles; metabolomic; OXIDE NANOPARTICLES; ZNO NANOPARTICLES; INDUCE APOPTOSIS; IN-VITRO; CELLS; ANTICANCER; TOXICITY;

D O I：

10.3390/nu12113457

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The cytotoxic properties of zinc nanoparticles have been evaluated in vitro against several types of cancer. However, there is a lack of significant evidence of their activity in vivo, and a potential therapeutic application remains limited. Herein we report the effective inhibition of tumor growth by zinc nanoparticles in vivo, as the effect of the dietary intervention, after the chemical induction in a rodent model of breast cancer. Biopsy images indicated grade 1 tumors with multiple inflammatory infiltrates in the group treated with zinc nanoparticles, whereas, in the other groups, a moderately differentiated grade 2 adenocarcinoma was identified. Moreover, after the supplementation with zinc nanoparticles, the levels of several metabolites associated with cancer metabolism, important to its survival, were found to have been altered. We also revealed that the biological activity of zinc in vivo depends on the size of applied particles, as the treatment with zinc microparticles has not had much effect on cancer progression.

引用

页码：1 / 14

页数：14

共 36 条

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