Recent Advances on Octahedral Polypyridyl Ruthenium(II) Complexes as Antimicrobial Agents

被引：42

作者：

Yang, Yulin ^{[1
]}

Liao, Guojian ^{[1
]}

Fu, Chen ^{[1
]}

机构：

[1] Southwest Univ, Coll Pharmaceut Sci, Chongqing 400715, Peoples R China

来源：

POLYMERS | 2018年 / 10卷 / 06期

基金：

中国国家自然科学基金;

关键词：

polypyridyl; octahedral; ruthenium complex; antimicrobial activities; TRANSITION-METAL-COMPLEXES; CANCER-THERAPY; ANTICANCER ACTIVITY; DNA; RESISTANCE; BINDING; DRUGS; ANTIBIOTICS; BACTERIA; DESIGN;

D O I：

10.3390/polym10060650

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Recent developments of therapeutic agents based on transition metals have attracted a great deal of attention. Metal drugs have advantages over other small molecule drugs, and it was demonstrated that, in a number of studies, they played an important role in pharmaceutical chemical research and clinical chemotherapy of cancers. It is worthwhile mentioning that octahedral polypyridyl ruthenium(II) complexes have shown remarkable applications in chemical biology and medicinal chemistry over the last decade. However, only very recently has there been comprehensive interest in their antimicrobial properties due to metal-related toxic concerns or neglected potential roles in microbiological systems. Our review will highlight the recent developments in octahedral polypyridyl ruthenium(III) complexes that have exhibited significant antimicrobial activities and will discuss the relationship between the chemical structure and biological process of ruthenium complexes, in both bacterial and fungal cells.

引用

页数：12

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