Frequencies of bovine PrP gene polymorphisms in Holstein and Japanese Black bulls in Japan

被引：5

作者：

Abe, Tsuyoshi ^{[1
]}

Hasebe, Hiroyuki ^{[1
]}

Kobayashi, Eiji ^{[1
]}

机构：

[1] Natl Livestock Breeding Ctr, Fukushima 9618511, Japan

来源：

ANIMAL SCIENCE JOURNAL | 2006年 / 77卷 / 04期

关键词：

bull; genotype frequency; Holstein; Japanese Black; prion;

D O I：

10.1111/j.1740-0929.2006.00364.x

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

We screened for Japanese Black and Holstein bull sire samples to detect single nucleotide polymorphisms (SNPs) involving animo-acid substitutions in the bovine prion gene in the entire coding region of the PRNP gene. Although three silent SNPs were found, we could not detect any SNP with animo-acid substitution. We also examined the polymorphism of the octapeptide repeat number in these samples. There was no homozygous bull with repeat number 5. The frequency of heterozygous (6/5) bulls was 8% in the Japanese Black bull and 4% in the Holstein bull, respectively. The bull samples used in this study contain popular elite sires, so it appears that the polymorphisms of prion protein (PrP) are rather difficult to find in these two breeds in Japan, except for polymorphism of the octapeptide repeat number.

引用

页码：395 / 398

页数：4

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