EGFR mutations in lung cancer:: Correlation with clinical response to gefitinib therapy

被引：7811

作者：

Paez, JG

Jänne, PA

Lee, JC

Tracy, S

Greulich, H

Gabriel, S

Herman, P

Kaye, FJ

Lindeman, N

Boggon, TJ

Naoki, K

Sasaki, H

Fujii, Y

Eck, MJ

Sellers, WR ^{[1
]}

Johnson, BE

Meyerson, M

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[2] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

[5] Harvard Univ, Sch Med, Dept Biol Chem, Boston, MA 02115 USA

[6] Harvard Univ, Sch Med, Dept Mol Pharmacol, Boston, MA 02115 USA

[7] MIT & Harvard, Broad Inst, Cambridge, MA 02142 USA

[8] Natl Naval Med Res Inst, Genet Branch, NCI, Bethesda, MD 20889 USA

[9] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[10] Nagoya City Univ, Sch Med, Dept Surg 2, Nagoya, Aichi 4678601, Japan

来源：

SCIENCE | 2004年 / 304卷 / 5676期

关键词：

D O I：

10.1126/science.1099314

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Receptor tyrosine kinase genes were sequenced in non - small cell lung cancer (NSCLC) and matched normal tissue. Somatic mutations of the epidermal growth factor receptor gene EGFR were found in 15 of 58 unselected tumors from Japan and 1 of 61 from the United States. Treatment with the EGFR kinase inhibitor gefitinib (Iressa) causes tumor regression in some patients with NSCLC, more frequently in Japan. EGFR mutations were found in additional lung cancer samples from U. S. patients who responded to gefitinib therapy and in a lung adenocarcinoma cell line that was hypersensitive to growth inhibition by gefitinib, but not in gefitinib-insensitive tumors or cell lines. These results suggest that EGFR mutations may predict sensitivity to gefitinib.

引用

页码：1497 / 1500

页数：4

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