Hyperthermic Intraperitoneal Chemotherapy as a Treatment for Epithelial Ovarian Cancer

被引：1

作者：

Fahim, Mohamed Ibrahim ^{[1
]}

Nassar, Omaya Abdelhamid ^{[1
]}

Mansour, Osman Mohamed ^{[2
]}

Ali, Abdelmaksoud Mohamed ^{[1
]}

Mahmoud, Ahmed-Mostafa ^{[1
]}

Hafez, Nesreen Hassan ^{[3
]}

Allam, Rasha Mahmoud ^{[4
]}

Kamal, Amr ^{[1
]}

Ghareeb, Mohamed ^{[2
]}

机构：

[1] Cairo Univ, Natl Canc Inst, Dept Surg Oncol, 1 Kasr El Aini St, Cairo 11796, Egypt

[2] Cairo Univ, Natl Canc Inst, Dept Med Oncol, Cairo, Egypt

[3] Cairo Univ, Natl Canc Inst, Dept Pathol, Cairo, Egypt

[4] Cairo Univ, Natl Canc Inst, Biostat & Canc Epidemiol Dept, Cairo, Egypt

来源：

INDIAN JOURNAL OF SURGICAL ONCOLOGY | 2019年 / 10卷 / 03期

关键词：

Epithelial ovarian cancer (EOC); Peritoneal carcinomatosis; Peritoneal cancer index (PCI); Cytoreductive surgery (CRS); Hyperthermic intraperitoneal chemotherapy (HIPEC); CYTOREDUCTIVE SURGERY; HIPEC;

D O I：

10.1007/s13193-018-0867-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Treatment by cytoreductive surgery (CRS) and intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) has been an option for selected patients with peritoneal carcinomatosis. This study aims to evaluate the impact of HIPEC in epithelial ovarian cancer (EOC). A retrospective observational cohort study including 48 EOC patients treated and followed up between 2012 and 2016. Thirty-seven cases were treated by CRS only, while 11 cases were treated by CRS and HIPEC. The study was performed at National Cancer Institute (NCI)-Cairo University. There was no statistically significant difference regarding overall survival or disease-free survival between the group of EOC patients treated by CRS only and the one treated by CRS and HIPEC. Presence of ascites and histological types (serous/non-serous) were the significant independent variables related to overall survival. Presence of ascites was the only independent variable associated with a significant relation to disease-free survival. No statistically significant impact of HIPEC in treatment of EOC was found in this study.

引用

页码：417 / 421

页数：5

共 7 条

[1] Treatment of Microscopic Disease with Hyperthermic Intraoperative Intraperitoneal Chemotherapy After Complete Cytoreduction Improves Disease-Free Survival in Patients with Stage IIIC/IV Ovarian Cancer [J].

Antonio Cascales-Campos, Pedro ;

Gil, J. ;

Gil, E. ;

Feliciangeli, E. ;

Gonzalez-Gil, A. ;

Parrilla, J. J. ;

Parrilla, P. .

ANNALS OF SURGICAL ONCOLOGY, 2014, 21 (07) :2383-2389

[2] Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for the treatment of advanced epithelial ovarian carcinoma: Upfront therapy, at first recurrence, or later? [J].

Gonzalez Bayon, L. ;

Steiner, M. A. ;

Vasquez Jimenez, W. ;

Asencio, J. M. ;

Alvarez de Sierra, P. ;

Atahualpa Arenas, F. ;

Rodriguez del Campo, J. ;

Garcia Sabrido, J. L. .

EJSO, 2013, 39 (10) :1109-1115

[3] Ovarian cancer [J].

Hennessy, Bryan T. ;

Coleman, Robert L. ;

Markman, Maurie .

LANCET, 2009, 374 (9698) :1371-1382

[4] Hyper:thermic intraperitoneal chemotherapy (HIPEC) and cytoreductive surgery (CRS) in ovarian cancer: A systematic review and meta-analysis [J].

Huo, Y. R. ;

Richards, A. ;

Liauw, W. ;

Morris, D. L. .

EJSO, 2015, 41 (12) :1578-1589

[5]

Manzanedo I, 2017, MINERVA GINECOL, V69, P119, DOI 10.23736/S0026-4784.16.03959-9

[6] Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer [J].

van Driel, W. J. ;

Koole, S. N. ;

Sikorska, K. ;

van Leeuwen, J. H. Schagen ;

Schreuder, H. W. R. ;

Hermans, R. H. M. ;

de Hingh, I. H. J. T. ;

van der Velden, J. ;

Arts, H. J. ;

Massuger, L. F. A. G. ;

Aalbers, A. G. J. ;

Verwaal, V. J. ;

Kieffer, J. M. ;

Van de Vijver, K. K. ;

van Tinteren, H. ;

Aaronson, N. K. ;

Sonke, G. S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (03) :230-240

[7]

Warschkow R, 2012, PATIENT SAF SURG, V6, DOI 10.1186/1754-9493-6-12

← 1 →