Synthesis of a hydrophilic and non-ionic anthracene derivative, the N,N′-di-(2,3-dihydroxypropyl)-9,10-anthracenedipropanamide as a chemical trap for singlet molecular oxygen detection in biological systems

被引：28

作者：

Martinez, Glaucia R.

Garcia, Flavia

Catalani, Luiz H.

Cadet, Jean

Oliveira, Mauricio C. B.

Ronsein, Graziella E.

Miyamoto, Sayuri

Medeiros, Marisa H. G.

Di Mascio, Paolo

机构：

[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-05513970 Sao Paulo, Brazil

[2] Univ Fed Parana, Dept Bioquim & Biol Mol, Setor Ciencias Biol, BR-80060000 Curitiba, Parana, Brazil

[3] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, Sao Paulo, Brazil

[4] CEA, UMR E3, LCIB, DRFMC,Lab Les Acides Nucl, F-38054 Grenoble 9, France

来源：

TETRAHEDRON | 2006年 / 62卷 / 46期

基金：

巴西圣保罗研究基金会;

关键词：

anthracene; endoperoxide; HPLC-MS; singlet oxygen; trap; probe;

D O I：

10.1016/j.tet.2006.08.094

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report herein the synthesis of a new hydrophilic and non-ionic anthracene derivative, the N,N'-di-(2,3-dihydroxypropyl)-9,10-anthracenedipropanamide. The evaluation of this compound as chemical trap of singlet molecular oxygen by using labeling experiments and HPLC-MS analysis showed that it could be efficiently used in biological investigations. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：10762 / 10770

页数：9

共 35 条

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