Chemokines: directing leukocyte infiltration into allografts

被引：119
作者：
El-Sawy, T
Fahmy, NM
Fairchild, RL
机构：
[1] Cleveland Clin Fdn, Dept Immunol, Cleveland, OH 44195 USA
[2] Cleveland Clin Fdn, Inst Urol, Cleveland, OH 44195 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 05期
关键词：
D O I：
10.1016/S0952-7915(02)00382-5
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Chemokines have been shown to play a critical role in the recruitment of leukocytes to transplanted organs. Animal models and clinical studies have demonstrated predictable temporal and spatial correlations between chemokine production and leukocyte infiltration into allografts. Antagonism of chemokines or chemokine receptors has been shown to delay leukocyte infiltration and prolong graft function, demonstrating an important role for chemokines in allograft rejection. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：562 / 568
页数：7
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