Microwave-assisted solid-phase synthesis (MASS) of 2,6,9-trisubstituted purines

被引：33
作者：
Austin, RE [1 ]
Okonya, JF [1 ]
Bond, DRS [1 ]
Al-Obeidi, F [1 ]
机构：
[1] Selectide, Tucson, AZ 85737 USA
来源：
TETRAHEDRON LETTERS | 2002年 / 43卷 / 35期
关键词：
D O I：
10.1016/S0040-4039(02)01271-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In an attempt to discover a high-throughput method for the synthesis of 2,6,9-trisubstituted purines, it was found that microwave irradiation was beneficial in accelerating the nucleophilic displacement of halogens by amines at the C-2 position of the purine nucleus. A method for microwave-assisted solid-phase synthesis (MASS) of 2,6,9-trisubstituted purines is presented. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：6169 / 6171
页数：3
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