ASSOCIATIONS BETWEEN TRIGLYCERIDE/HIGH-DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND MICRO- AND MACROANGIOPATHIES IN TYPE 2 DIABETES MELLITUS

被引：23

作者：

Lee, Mei-Yueh ^{[1
,2
,3
,4
]}

Hsiao, Pi-Jung ^{[2
,4
]}

Huang, Jiun-Chi ^{[1
,3
,4
,5
]}

Hsu, Wei-Hao ^{[2
,3
]}

Chen, Szu-Chia ^{[3
,4
,5
]}

Chang, Jer-Ming ^{[4
,5
]}

Shin, Shyi-Jang ^{[2
,4
,6
]}

机构：

[1] Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung, Taiwan

[2] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Endocrinol & Metab, Kaohsiung, Taiwan

[3] Kaohsiung Med Univ, Kaohsiung Municipal Hsiao Kang Hosp, Dept Internal Med, 482 Shan Ming Rd, Kaohsiung 812, Taiwan

[4] Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung, Taiwan

[5] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung, Taiwan

[6] Kaohsiung Med Univ, Ctr Lipid & Glycomed Res, Kaohsiung, Taiwan

来源：

ENDOCRINE PRACTICE | 2018年 / 24卷 / 07期

关键词：

RISK-FACTORS; RETINOPATHY; PROGRESSION; COMPLICATIONS; ATHEROSCLEROSIS; CREATININE; PREVENTION; PREDICTION; DISEASE; LIPIDS;

D O I：

10.4158/EP-2017-0254

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio has been reported to be a marker of insulin resistance. The aim of this study was to investigate associations between the TG/HDL-C ratio and micro- and microangiopathies in patients with type 2 diabetes mellitus (DM). Methods: A total of 1,981 (851 male and 1,130 female) patients with type 2 DM were enrolled from our outpatient clinic. These patients were stratified into 4 groups according to TG/HDL-C ratio quartiles. Results: There were significant trends for stepwise increases in albuminuria >= 30 mg/g (P<.001), coronary artery disease (CAD, P = .040), cerebrovascular disease (CVA, P = .002) and ankle-brachial index (AB1) <0.9 (P = .001) corresponding to TG/HDL-C ratio quartiles, but not diabetic retinopathy (P = .105). Furthermore, quartile 4 of the TG/HDL-C ratio was significantly associated with albuminuria, CAD, CVA, and ABI <0.9 after multivariate analysis compared to quartile 1. Conclusion: A high TG/HDL-C ratio was significantly associated with albuminuria, CAD, CVA, and peripheral artery occlusive disease (PAOD) in patients with DM, which translated into an increased risk of cardiovascular disease.

引用

页码：615 / 621

页数：7

共 37 条

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