Deamino-hydroxy-phoslactomycin B, a biosynthetic precursor of phoslactomycin, induces myeloid differentiation in HL-60 cells

被引：14
作者：
Simizu, Siro [1 ,2 ]
Teruya, Takayuki [1 ,2 ]
Nogawa, Toshihiko [1 ,2 ]
Aono, Harumi [1 ,2 ]
Ueki, Masashi [1 ,2 ]
Uramoto, Masakazu [1 ,2 ]
Kobayashi, Yuichi [3 ]
Osada, Hiroyuki [1 ,2 ]
机构：
[1] RIKEN, Antibiot Lab, Wako, Saitama 3510198, Japan
[2] RIKEN, Dept Biol Chem, Wako, Saitama 3510198, Japan
[3] Tokyo Inst Technol, Dept Biomol Engn, Midori Ku, Yokohama, Kanagawa 2268501, Japan
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 383卷 / 04期
关键词：
Differentiation; Phoslactomycin; Protein phosphatase 2A; HL-60; Natural product; All-trans retinoic acid; Cell cycle; Vitamin D-3; Acute myeloid leukemia; PROMYELOCYTIC LEUKEMIA; MICROBIAL METABOLITES; NATURAL-PRODUCTS; SCREENING METHOD; PROTEIN; INHIBITORS; IDENTIFICATION; ACID; FERMENTATION; TAXONOMY;
D O I：
10.1016/j.bbrc.2009.04.014
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
During the screening for novel differentiation inducers, we found that a culture broth of Streptomyces sp. HK-803 induced myeloid differentiation of HL-60 cells. The active substance was identified as deamino-hydroxy-phoslactomycin B (HPLM) by mass spectrometry, and synthesized HPLM also induced the differentiation of HL-60 cells. HPLM showed greater inhibition of protein phosphatase 2A (PP2A) activity than phoslactomycin B (PLMB); however, PLMB and okadaic acid did not induce differentiation. Moreover, treatment with ATRA and 1 alpha, 25(OH)(2)D-3 induced retinoic acid receptor-beta and 1 alpha, 25(OH)(2) D-3 24-hydroxylase, respectively, whereas HPLM did not, suggesting that HPLM is a novel differentiation inducer. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：406 / 410
页数：5
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