Deamino-hydroxy-phoslactomycin B, a biosynthetic precursor of phoslactomycin, induces myeloid differentiation in HL-60 cells

被引：14

作者：

Simizu, Siro ^{[1
,2
]}

Teruya, Takayuki ^{[1
,2
]}

Nogawa, Toshihiko ^{[1
,2
]}

Aono, Harumi ^{[1
,2
]}

Ueki, Masashi ^{[1
,2
]}

Uramoto, Masakazu ^{[1
,2
]}

Kobayashi, Yuichi ^{[3
]}

Osada, Hiroyuki ^{[1
,2
]}

机构：

[1] RIKEN, Antibiot Lab, Wako, Saitama 3510198, Japan

[2] RIKEN, Dept Biol Chem, Wako, Saitama 3510198, Japan

[3] Tokyo Inst Technol, Dept Biomol Engn, Midori Ku, Yokohama, Kanagawa 2268501, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 383卷 / 04期

关键词：

Differentiation; Phoslactomycin; Protein phosphatase 2A; HL-60; Natural product; All-trans retinoic acid; Cell cycle; Vitamin D-3; Acute myeloid leukemia; PROMYELOCYTIC LEUKEMIA; MICROBIAL METABOLITES; NATURAL-PRODUCTS; SCREENING METHOD; PROTEIN; INHIBITORS; IDENTIFICATION; ACID; FERMENTATION; TAXONOMY;

D O I：

10.1016/j.bbrc.2009.04.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During the screening for novel differentiation inducers, we found that a culture broth of Streptomyces sp. HK-803 induced myeloid differentiation of HL-60 cells. The active substance was identified as deamino-hydroxy-phoslactomycin B (HPLM) by mass spectrometry, and synthesized HPLM also induced the differentiation of HL-60 cells. HPLM showed greater inhibition of protein phosphatase 2A (PP2A) activity than phoslactomycin B (PLMB); however, PLMB and okadaic acid did not induce differentiation. Moreover, treatment with ATRA and 1 alpha, 25(OH)(2)D-3 induced retinoic acid receptor-beta and 1 alpha, 25(OH)(2) D-3 24-hydroxylase, respectively, whereas HPLM did not, suggesting that HPLM is a novel differentiation inducer. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：406 / 410

页数：5

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