Molecular characterization of attenuated Junin virus strains

被引：37

作者：

Albarino, CG

Ghiringhelli, PD

Posik, DM

Lozano, ME

Ambrosio, AM

Sanchez, A

Romanowski, V

机构：

[1] NATL UNIV LA PLATA,FAC CIENCIAS EXACTAS,INST BIOQUIM & BIOL MOL,DEPT CIENCIAS BIOL,RA-1900 LA PLATA,ARGENTINA

[2] UNIV NACL QUILMES,DEPT CIENCIA & TECNOL,RA-1876 BERNAL,ARGENTINA

[3] INST ESTUDIOS ENFERMEDADES VIRALES HUMANAS,RA-2700 PERGAMINO,ARGENTINA

[4] CTR DIS CONTROL & PREVENT,DIV VIRAL & RICKETTSIAL DIS,SPECIAL PATHOGENS BRANCH,ATLANTA,GA 30333

来源：

JOURNAL OF GENERAL VIROLOGY | 1997年 / 78卷

关键词：

D O I：

10.1099/0022-1317-78-7-1605

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The Junin virus strain Candid #1 was developed as a live attenuated vaccine for Argentine haemorrhagic fever. In this paper we report the nucleotide sequences of S RNA of Candid #1 and its more virulent ancestors XJ#44 and XJ (prototype). Their relationship to Junin virus wild-type MC2 strain and other closely and distantly related arenaviruses was also examined. Comparisons of the nucleotide and amino acid sequences of N and GPC genes from Candid #1 and its progenitor strains revealed some changes that are unique to the vaccine strain. These changes could be provisionally associated with the attenuated phenotype.

引用

页码：1605 / 1610

页数：6

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