Effects of Vitamin E-Coated versus Conventional Membranes in Chronic Hemodialysis Patients: A Systematic Review and Meta-Analysis

被引:54
作者
D'Arrigo, Graziella [1 ]
Baggetta, Rossella [1 ]
Tripepi, Giovanni [1 ]
Galli, Francesco [2 ]
Bolignano, Davide [1 ]
机构
[1] CNR, Inst Clin Physiol, Reggio Di Calabria, Italy
[2] Univ Perugia, Dept Pharmaceut Sci, Nutr & Clin Biochem Lab, Perugia, Italy
关键词
Vitamin E-coated membrane; Oxidative stress; Inflammation; Anemia; Hemodialysis; LOW-DENSITY-LIPOPROTEIN; E-BONDED MEMBRANE; LONG-TERM USE; MODIFIED DIALYSIS MEMBRANE; REDUCES OXIDATIVE STRESS; DIALYZER MEMBRANE; INTRADIALYTIC HYPOTENSION; STIMULATING AGENTS; C INFUSION; POLYSULFONE;
D O I
10.1159/000453444
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Accruing evidence suggests that vitamin Ecoated membranes (ViE-m) might improve the clinical management of chronic hemodialysis (HD) patients. Methods: We conducted a systematic review and meta-analysis of RCTs comparing ViE-m to conventional HD. Endpoints of interest were a series of biomarkers pertaining to anemia status, inflammation, oxidative stress and dialysis efficacy/status. Results: Sixty studies were included. ViE-m significantly improved the Erythropoietin Resistance Index but had no impact on other anemia parameters. As for oxidative stress and inflammation, ViE-m produced a significant decrease in interleukin-6 levels, thiobarbituric acid reactive substances, plasma and red blood cell (RBC) malonylaldehyde and a significant increase in blood and RBC vitamin E. Conversely, ViE-m use had no impact on lipid profile, dialysis adequacy, blood pressure, albumin and uric acid. Conclusions: ViE-m might ameliorate anemia management by reducing oxidative stress and inflammation. Benefits of these bio-membranes on harder clinical outcomes are uncertain and need to be investigated by future, targeted trials. (C) 2016 S. Karger AG, Basel
引用
收藏
页码:101 / 122
页数:22
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