New cytotoxic sesquiterpene lactones from Anthemis scrobicularis

被引：7

作者：

Zaghloul, Ahmed M. ^{[1
,2
]}

Yusufoglu, Hasan S. ^{[1
]}

Salkini, Mohamad Ayman A. ^{[1
]}

Alam, Aftab ^{[1
]}

机构：

[1] Salman Bin Abdulaziz Univ, Coll Pharm, Dept Pharmacognosy, Al Kharj 11942, Saudi Arabia

[2] Mansoura Univ, Coll Pharm, Dept Pharmacognosy, Mansoura 35516, Egypt

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2014年 / 16卷 / 09期

关键词：

Anthemis scrobicularis; sesquiterpene lactone; cytotoxicity; TRANSFORMATIONS;

D O I：

10.1080/10286020.2014.931377

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new sesquiterpene lactones, 4 alpha-hydroxy-guaia-10(14), 11(13)-diene-12,6 alpha-olide (1), 4 alpha-hydroxy-9 alpha-acetoxy-guaia-1(10), 2-diene-12,6 alpha-olide (4), 4 alpha-hydroxy-9 beta-acetoxy-guaia-1(10), 2-diene-12,6 alpha-olide (5), and 1 alpha, 4 alpha-dihydroxy-9 alpha-acetoxyguaia-10(14), 2-diene-12,6 alpha-olide (6), were isolated from the aerial parts of Anthemis scrobicularis. Their structures were elucidated on the basis of their IR, NMR, and MS spectroscopic data. In addition, two known sesquiterpene lactones micheliolide (2) and achillin (3) were also isolated. The cytotoxicity of some of the isolated compounds was tested against HCT 116, HepG-2, and MCF-7 cell lines. Micheliolide and 4 alpha-hydroxy-guaia-10(14), 11(13)-diene-12,6 alpha-olide showed pronounced inhibitory activity while 4 alpha-hydroxy-9 alpha-acetoxy-guaia-1(10), 2-diene-12,6 alpha-olide showed weak activity.

引用

页码：922 / 929

页数：8

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