Two new indole-diterpenoids from the marine-derived fungus Penicillium sp. KFD28

被引：18
作者：
Chen, Ming-Yang [1 ]
Xie, Qing-Yi [2 ]
Kong, Fan-Dong [2 ]
Ma, Qing-Yun [2 ]
Zhou, Li-Man [2 ]
Yuan, Jing-Zhe [2 ]
Dai, Hao-Fu [2 ,3 ]
Wu, You-Gen [1 ]
Zhao, You-Xing [2 ,3 ]
机构：
[1] Hainan Univ, Coll Hort, Haikou 570228, Hainan, Peoples R China
[2] CATAS, Inst Trop Biosci & Biotechnol, Haikou Key Lab Res & Utilizat Trop Nat Prod, Haikou 571101, Hainan, Peoples R China
[3] CATAS, Hainan Acad Trop Agr Resource, Haikou 571101, Hainan, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2021年 / 23卷 / 11期
关键词：
Indole-diterpenoid; marine-derived fungus; Penicillium sp; protein phoshatases inhibitory activity; WORM;
D O I：
10.1080/10286020.2020.1849150
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new compounds named epipaxilline (1) and penerpene J (2) were isolated from the marine-derived fungus Penicillium sp. KFD28. Their structures including absolute configurations were determined on the basis of spectroscopic methods and ECD analysis. Compounds 1 and 2 showed inhibitory activities against PTP1B with IC50 values of 31.5 and 9.5 mu M, respectively, and compound 2 also showed inhibitory activities against TCPTP with IC50 value of 14.7 mu M.
引用
收藏
页码：1030 / 1036
页数：7
相关论文
共 13 条
[1]   Asperpenes D and E from the fungus Aspergillus sp. SCS-KFD66 isolated from a bivalve mollusk, Sanguinolaria chinensis [J].
An, Chang-Liang ;
Kong, Fan-Dong ;
Li, Yan ;
Ma, Qing-Yun ;
Xie, Qing-Yi ;
Yuan, Jing-Zhe ;
Zhou, Li-Man ;
Dai, Hao-Fu ;
Yu, Zhi-Fang ;
Zhao, You-Xing .
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2021, 23 (02) :117-122
[2]   Chemical Constituents of the Marine-Derived Fungus Aspergillus sp. SCS-KFD66 [J].
An, Chang-Liang ;
Kong, Fan-Dong ;
Ma, Qing-Yun ;
Xie, Qing-Yi ;
Yuan, Jing-Zhe ;
Zhou, Li-Man ;
Dai, Hao-Fu ;
Yu, Zhi-Fang ;
Zhao, You-Xing .
MARINE DRUGS, 2018, 16 (12)
[3]   Tyrosol from marine Fungi, a novel Quorum sensing inhibitor against Chromobacterium violaceum and Pseudomonas aeruginosa [J].
Chang, Aiping ;
Sun, Shiwei ;
Li, Li ;
Dai, Xiaoyun ;
Li, Hui ;
He, Qiaomei ;
Zhu, Hu .
BIOORGANIC CHEMISTRY, 2019, 91
[4]   A NEW AND RAPID COLORIMETRIC DETERMINATION OF ACETYLCHOLINESTERASE ACTIVITY [J].
ELLMAN, GL ;
COURTNEY, KD ;
ANDRES, V ;
FEATHERSTONE, RM .
BIOCHEMICAL PHARMACOLOGY, 1961, 7 (02) :88-&
[5]  
Fan Y, 2013, IEEE VEHICLE POWER, P77
[6]   Protein tyrosine phosphatases as potential therapeutic targets [J].
He, Rong-jun ;
Yu, Zhi-hong ;
Zhang, Ruo-yu ;
Zhang, Zhong-yin .
ACTA PHARMACOLOGICA SINICA, 2014, 35 (10) :1227-1246
[7]   α-Glucosidase inhibitors from Devil tree (Alstonia scholaris) [J].
Jong-Anurakkun, Nilubon ;
Bhandari, Megh Raj ;
Kawabata, Jun .
FOOD CHEMISTRY, 2007, 103 (04) :1319-1323
[8]   Metabolites with Gram-negative bacteria quorum sensing inhibitory activity from the marine animal endogenic fungus Penicillium sp SCS-KFD08 [J].
Kong, Fan Dong ;
Zhou, Li Man ;
Ma, Qing Yun ;
Huang, Sheng Zhuo ;
Wang, Pei ;
Dai, Hao Fu ;
Zhao, You Xing .
ARCHIVES OF PHARMACAL RESEARCH, 2017, 40 (01) :25-31
[9]   Penerpenes A-D, Four Indole Terpenoids with Potent Protein Tyrosine Phosphatase Inhibitory Activity from the Marine-Derived Fungus Penicillium sp. KFD28 [J].
Kong, Fan-Dong ;
Fan, Peng ;
Zhou, Li-Man ;
Ma, Qing-Yun ;
Xie, Qing-Yi ;
Zheng, Hai-Zhou ;
Zheng, Zhi-Hui ;
Zhang, Ren-Shuai ;
Yuan, Jing-Zhe ;
Dai, Hao-Fu ;
Luo, Du-Qiang ;
Zhao, You-Xing .
ORGANIC LETTERS, 2019, 21 (12) :4864-4867
[10]   Helvolic Acid Derivatives with Antibacterial Activities against Streptococcus agalactiae from the Marine-Derived Fungus Aspergillus fumigatus HNMF0047 [J].
Kong, Fan-Dong ;
Huang, Xiao-Long ;
Ma, Qing-Yun ;
Xie, Qing-Yi ;
Wang, Pei ;
Chen, Peng-Wei ;
Zhou, Li-Man ;
Yuan, Jing-Zhe ;
Dai, Hao-Fu ;
Luo, Du-Qiang ;
Zhao, You-Xing .
JOURNAL OF NATURAL PRODUCTS, 2018, 81 (08) :1869-1876
12