Non-uniformity of binder distribution in high-shear granulation

被引：40

作者：

Reynolds, GK ^{[1
]}

Biggs, CA ^{[1
]}

Salman, AD ^{[1
]}

Hounslow, MJ ^{[1
]}

机构：

[1] Univ Sheffield, Dept Chem & Proc Engn, Sheffield S1 3JD, S Yorkshire, England

来源：

POWDER TECHNOLOGY | 2004年 / 140卷 / 03期

关键词：

non-uniformity; binder distribution; high-shear granulation;

D O I：

10.1016/j.powtec.2004.01.017

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Further experimental investigation based on a microscopic, or single granule, scale has been conducted to investigate the uniformity of binder composition within a given size class for high shear melt granulation. This work assesses whether there is significant non-uniformity of binder composition within size classes to warrant considering this level of detail to improving population balance modelling of high shear granulation. It is concluded that at early times in a batch granulation process there is a broad variation in binder content between individual granules and that this variation persists in granules of small size. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：203 / 208

页数：6

共 8 条

[1] Coupling granule properties and granulation rates in high-shear granulation [J].

Biggs, CA ;

Sanders, C ;

Scott, AC ;

Willemse, AW ;

Hoffman, AC ;

Instone, T ;

Salman, AD ;

Hounslow, MJ .

POWDER TECHNOLOGY, 2003, 130 (1-3) :162-168

[2] An experimental study of the variability in the properties and quality of wet granules [J].

Fu, JS ;

Cheong, YS ;

Reynolds, GK ;

Adams, MJ ;

Salman, AD ;

Hounslow, MJ .

POWDER TECHNOLOGY, 2004, 140 (03) :209-216

[3] Limitations of one-dimensional population balance models of wet granulation processes [J].

Iveson, SM .

POWDER TECHNOLOGY, 2002, 124 (03) :219-229

[4] Effects of interactions between powder particle size and binder viscosity on agglomerate growth mechanisms in a high shear mixer [J].

Johansen, A ;

Schæfer, T .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2001, 12 (03) :297-309

[5] An investigation into the kinetics of liquid distribution and growth in high shear mixer agglomeration [J].

Knight, PC ;

Instone, T ;

Pearson, JMK ;

Hounslow, MJ .

POWDER TECHNOLOGY, 1998, 97 (03) :246-257

[6] MECHANICAL-PROPERTIES OF MOIST AGGLOMERATES IN RELATION TO GRANULATION MECHANISMS .1. DEFORMABILITY OF MOIST, DENSIFIED AGGLOMERATES [J].

KRISTENSEN, HG ;

HOLM, P ;

SCHAEFER, T .

POWDER TECHNOLOGY, 1985, 44 (03) :227-237

[7] Direct evidence of heterogeneity during high-shear granulation [J].

Scott, AC ;

Hounslow, MJ ;

Instone, T .

POWDER TECHNOLOGY, 2000, 113 (1-2) :205-213

[8] Growth mechanisms of high-shear pelletisation [J].

Vonk, P ;

Guillaume, CPF ;

Ramaker, JS ;

Vromans, H ;

Kossen, NWF .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1997, 157 (01) :93-102

← 1 →