Siphonazole, an unusual metabolite from Herpetosiphon sp.

被引：59
作者：
Nett, Markus
Erol, Oezlem
Kehraus, Stefan
Koeck, Matthias
Krick, Anja
Eguereva, Ekaterina
Neu, Edith
Koenig, Gabriele M.
机构：
[1] Univ Bonn, Inst Pharmaceut Biol, D-53115 Bonn, Germany
[2] Alfred Wegener Inst Polar & Marine Res, D-27570 Bremerhaven, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 23期
关键词：
biosynthesis; herpetosiphon; natural products; siphonazole; structure elucidation;
D O I：
10.1002/anie.200504525
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Deep and complex: The first representative (see picture) of a new structural class has been isolated from a deep-rooted filamentous bacterium of the genus Herpetosiphon. Feeding with 13C and 15N-labeled precursors showed the complex biosynthesis to involve shikimate, the polyketide, and the amino acid metabolism. (Figure Presented) © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：3863 / 3867
页数：5
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