Stem cell-based therapy for neonatal lung disease: it is in the juice

被引：66
作者：
Fung, Moses E. [1 ,2 ]
Thebaud, Bernard [3 ,4 ]
机构：
[1] Univ Alberta, Cardiovasc Res Ctr, Women & Childrens Hlth Res Inst, Edmonton, AB, Canada
[2] Univ Alberta, Pulm Res Grp, Edmonton, AB, Canada
[3] Ottawa Hosp, Res Inst, Regenerat Med Program, Sprott Ctr Stem Cell Res, Ottawa, ON, Canada
[4] Univ Ottawa, Dept Pediat, Eastern Ontario Res Inst, Childrens Hosp, Ottawa, ON K1N 6N5, Canada
来源：
PEDIATRIC RESEARCH | 2014年 / 75卷 / 01期
关键词：
MARROW STROMAL CELLS; CORD BLOOD; PROGENITOR CELLS; LONG-TERM; INJURY; HYPEROXIA; ALVEOLAR; GROWTH; REPAIR; MICE;
D O I：
10.1038/pr.2013.176
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Bronchopulmonary dysplasia, the chronic lung disease of prematurity, is the most common complication in extremely premature infants (born before 28wk gestation). Despite advances in perinatal care, modern clinical management remains devoid of therapies specifically promoting lung repair and lung growth. Recent progress in stem cell biology has uncovered the promise of stem/progenitor cells to repair damaged organs. Contrary to the original theory that stem cells engraft and repopulate the damaged organ, evidence suggests that stem cells act via a paracrine mechanism. This review highlights the preclinical evidence for the therapeutic potential of cell-based therapies in animal models of neonatal chronic lung injury and the multiple therapeutic avenues offered by soluble stem cell-derived factors.
引用
收藏
页码：2 / 7
页数：6
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