Angiogenesis in Waldenstrom's Macroglobulinemia

被引：12

作者：

Terpos, Evangelos ^{[1
]}

Tasidou, Anna ^{[2
]}

Kastritis, Efstathios ^{[1
]}

Eleftherakis-Papaiakovou, Evangelos ^{[1
]}

Gavriatopoulou, Maria ^{[1
]}

Migkou, Magdalini ^{[1
]}

Dimopoulos, Meletios-Athanassios ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Dept Clin Therapeut, Athens 14572, Greece

[2] Evangelismos Gen Hosp, Dept Hematopathol, Athens, Greece

来源：

CLINICAL LYMPHOMA & MYELOMA | 2009年 / 9卷 / 01期

关键词：

Angiogenin; Angiopoietins; Macrophage inflammatory protein-1 alpha; Mast cells; Vascular endothelial growth factor; MAST-CELLS; MACROPHAGES; THALIDOMIDE; DISEASE; GROWTH; CANCER;

D O I：

10.3816/CLM.2009.n.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Angiogenesis represents an essential step of disease progression in several hematological malignancies. In Waldenstrom's macroglobulinemia (WM) the bone marrow microvessel density is increased in 30%-40% of patients but seems to have no impact on survival. Angiogenic cytokines, such as angiogenin, vascular endothelial growth factor, and basic fibroblast growth factor are increased in the serum of WM or IgM-MGUS patients, while the ratio of angiopoietin-1/angiopoietin-2 is reduced in WM but not in IgM-monoclonal gammopathy of undetermined significance (MGUS). Angiogenin and angiopoietin-1/angiopoietin-2 ratio correlates with disease activity and clinical features of WM. Macrophage and mast-cell chemoattractants, such as macrophage inflammatory protein-1 alpha are also elevated in the serum of patients with WM, while both macrophages and mast cells that are increased in the WM microenvironment have angiogenic properties and participate in the angiogenesis process in several malignancies. This review summarizes all data available by November 2008 (end of literature search) for the role of angiogenesis in the biology of WM and its correlation with clinical and laboratory features of the disease.

引用

页码：46 / 49

页数：4

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