Synthesis and the hepatoprotective activity of dibenzocyclooctadiene lignan derivatives

被引：12

作者：

He, Tao ^{[1
,2
]}

Wang, Qing-Yao ^{[1
,2
,3
]}

Shi, Jing-Zhen ^{[4
]}

Fan, Tian-Yun ^{[1
,2
,3
]}

Yan, Chen ^{[1
,2
]}

Huang, Lie-Jun ^{[1
,2
]}

Liu, Sheng ^{[1
,2
]}

Hao, Xiao-Jiang ^{[1
,2
]}

Mu, Shu-Zhen ^{[1
,2
]}

机构：

[1] Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Guizhou, Peoples R China

[2] Chinese Acad Sci, Guiyang 550002, Guizhou, Peoples R China

[3] Guizhou Univ, Coll Pharmaceut Sci, Guiyang 550025, Guizhou, Peoples R China

[4] Guiyang Coll Tradit Chinese Med, Guiyang 550002, Guizhou, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 07期

关键词：

Schizandrin; Schizandrin B; Schisanhenol; Dibenzocyclooctadiene lignan derivatives; Hepatoprotective effect;

D O I：

10.1016/j.bmcl.2014.02.020

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The halogenated and oxidized derivatives (1a- 1e,1a'-1c', 2a-2d, 2a'-2b', 3a-3e, 3' and 3a'-3b') of schizandrin (1), schizandrin B (2) and schisanhenol (1) were synthesized. The hepatoprotective effects of these dibenzocyclooctadiene lignan analogues against CCl4-induced injury were preliminarily evaluated. Most of the analogues exhibited higher protective effects than the positive control biphenyldicarboxylate (DDB). Among these active analogues, dichloroschisanhenol (3a) exhibited the strongest protective activity (cell survival rate exceeding 98.0%). (c) 2014 Elsevier Ltd. All rights reserved.

引用

页码：1808 / 1811

页数：4

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