Not so Fas: Re-evaluating the mechanisms of immune privilege and tumor escape

被引：206
作者：
Restifo, NP [1 ]
机构：
[1] NCI, NIH, Bethesda, MD 20892 USA
来源：
NATURE MEDICINE | 2000年 / 6卷 / 05期
关键词：
D O I：
10.1038/74955
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Based on early studies, it was hypothesized that expression of Fas ligand (FasL) by tumor cells enabled them to counterattack the immune system, and that transplant rejection could be prevented by expressing FasL on transplanted organs. More recent studies have indicated that the notion of FasL as a mediator of immune privilege needed to be reconsidered, and taught a valuable lesson about making broad conclusions based on small amounts of data.
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收藏
页码：493 / 495
页数：3
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