Interferon-β modulates protein synthesis in the central nervous system

被引：7

作者：

Beyer, Susanne ^{[1
]}

Raether, Gergana ^{[1
]}

Stadler, Konstantin ^{[2
]}

Hoffrogge, Raimund ^{[3
]}

Scharf, Christian ^{[4
]}

Rolfs, Arndt ^{[5
]}

Mix, Eilhard ^{[1
]}

Strauss, Ulf ^{[1
,2
]}

机构：

[1] Univ Rostock, Dept Neurol, D-18147 Rostock, Germany

[2] Univ Med Berlin Charite, Dept Cell & Neurobiol, D-10115 Berlin, Germany

[3] Univ Bielefeld, Dept Cell Culture Tech, Tech Fac, D-33501 Bielefeld, Germany

[4] Ernst Moritz Arndt Univ Greifswald, Dept Otorhinolaryngol Head & Neck Surg, D-17475 Greifswald, Germany

[5] Univ Rostock, Albrecht Kossel Inst Neurogenerat, D-18147 Rostock, Germany

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2009年 / 213卷 / 1-2期

关键词：

Cycloheximide; Mass spectrometry; Intracellular recordings; Cortical neurons; Cytokines; GEL-ELECTROPHORESIS; I-INTERFERON; RAT; EXPRESSION; KINASE; CYCLOHEXIMIDE; ACTIVATION; MECHANISMS; RESPONSES; CYTOKINE;

D O I：

10.1016/j.jneuroim.2009.06.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interferon-beta (IFN-beta), acting canonically via the modulation of transcription, affects neocortical pyramidal neurons. By use of 2-D differential gel electrophoresis and subsequent mass spectrometry we identified IFN-beta regulated proteins in the central nervous system. These proteins are involved in cytoskeleton assembly, protein transport and nucleotide metabolism and, as such, serve regenerative and protective functions. Electrophysiologically, IFN-beta mediated protein synthesis is essential for part of the excitatory neuronal effects, as revealed under blockade of protein biosynthesis. This study presents novel effects of IFN-beta in the central nervous system and begins to unravel the mechanism behind the known excitability changes in neurons. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：31 / 38

页数：8

共 48 条

[1] Interferon beta promotes survival in primary astrocytes through phosphatidylinositol 3-kinase [J].