Porous silica nanoparticles capped with polyethylenimine/green carbon dots for pH/redox responsive drug release

被引：7

作者：

Zhang, Qianqian ^{[1
]}

Li, Xinli ^{[1
]}

Peng, Lichao ^{[1
]}

Zou, Xueyan ^{[1
]}

Zhao, Yanbao ^{[1
]}

机构：

[1] Henan Univ, Engn Res Ctr Nanomat, Kaifeng 475004, Peoples R China

来源：

INORGANIC CHEMISTRY COMMUNICATIONS | 2021年 / 123卷

关键词：

Porous silica nanoparticles; pH/redox responsive; Drug delivery; Green carbon dots; Fluorescent monitoring;

D O I：

10.1016/j.inoche.2020.108340

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Porous silica (pSiO(2)) nanoparticles (NPs) were prepared by hydrolysis method and engineered with disulfide linked gatekeepers for controlled drug release. The pSiO(2) NPs with large pores have an average diameter of 60 nm and are suitable for loading drug. Cysteine (Cys) molecules as disulfide-linkers were grafting on the surface of pSiO(2) carriers. After loading doxorubicin (DOX), polyethylenimine (PEI) and green carbon dots (gCDs) were used to cap the drug-loading pores. The PEI/gCDs shell can be detached from the surface of pSiO(2) carriers at tumor-relevant glutathione (GSH) levels and facilitate the release of the encapsulated cargo. Meanwhile, the PEI chains would be highly protonated and lead to the swelling of PEI layer at low pH value. The pSiO(2)-PEI/gCDs displayed good pH/redox-responsive release behavior and gCDs can be used to monitor the drug release.

引用

页数：7

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