Genome-wide identification of genes likely to be involved in human genetic disease

被引：190

作者：

López-Bigas, N ^{[1
]}

Ouzounis, CA ^{[1
]}

机构：

[1] EMBL, Computat Genom Grp, European Bioinformat Inst, Cambridge Outstation, Cambridge CB10 1SD, England

来源：

NUCLEIC ACIDS RESEARCH | 2004年 / 32卷 / 10期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1093/nar/gkh605

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sequence analysis of the group of proteins known to be associated with hereditary diseases allows the detection of key distinctive features shared within this group. The disease proteins are characterized by greater length of their amino acid sequence, a broader phylogenetic extent, and specific conservation and paralogy profiles compared with all human proteins. This unique property pattern provides insights into the global nature of hereditary diseases and moreover can be used to predict novel disease genes. We have developed a computational method that allows the detection of genes likely to be involved in hereditary disease in the human genome. The probability score assignments for the human genome are accessible at http://maine.ebi. ac.uk:8000/services/dgp.

引用

页码：3108 / 3114

页数：7

共 32 条

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