Nitrofurantoin-Induced Granulomatous Interstitial Pneumonia

被引:9
作者
Sakata, Kenneth K. [1 ]
Larsen, Brandon T. [2 ]
Boland, Jennifer M. [2 ]
Palen, Brian [1 ]
Muhm, John R., Sr. [1 ]
Helmers, Richard A. [1 ]
Tazelaar, Henry D. [1 ]
机构
[1] Mayo Clin, Scottsdale, AZ 85259 USA
[2] Mayo Clin, Rochester, MN USA
关键词
toxicity; granulomas; nitrofurantoin; lung; METHOTREXATE-INDUCED PNEUMONITIS; RHEUMATOID-ARTHRITIS; PULMONARY REACTIONS; LUNG NODULES; BLEOMYCIN; SUBACUTE;
D O I
10.1177/1066896913492849
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Nitrofurantoin-induced lung toxicity is relatively common, but rare histologic patterns sometimes occur that may make diagnosis difficult. We present the case of a 69-year-old woman taking prophylactic nitrofurantoin for urinary tract infections, who developed granulomatous interstitial pneumonia. She improved with cessation of nitrofurantoin, without other therapy. To our knowledge, this is the fourth reported case of granulomatous interstitial pneumonia associated with nitrofurantoin, and the first to show complete resolution with cessation of the drug alone, without steroids. It is important to recognize that idiosyncratic reactions to nitrofurantoin can produce a wide spectrum of histologic patterns. Of these patterns, granulomatous interstitial pneumonia is a rarely evidenced manifestation (possibly because few cases undergo a confirmatory lung biopsy). Recognition of granulomatous interstitial pneumonia as a manifestation of nitrofurantoin toxicity can aid in early identification of the reaction and prompt withdrawal of the drug, both of which are essential to prevent long-term complications.
引用
收藏
页码:352 / 357
页数:6
相关论文
共 28 条
[21]  
SCHWARTZ GF, 1990, J RHEUMATOL, V17, P980
[22]   NITROFURANTOIN-INDUCED GRANULOMATOUS HEPATITIS [J].
SIPPEL, PJ ;
AGGER, WA .
UROLOGY, 1981, 18 (02) :177-178
[23]   METHOTREXATE-INDUCED PNEUMONITIS [J].
SOSTMAN, HD ;
MATTHAY, RA ;
PUTMAN, CE ;
SMITH, GJW .
MEDICINE, 1976, 55 (05) :371-388
[24]  
SOVIJARVI ARA, 1977, SCAND J RESPIR DIS, V58, P41
[25]   CAVITARY LUNG NODULES ASSOCIATED WITH COMBINATION CHEMOTHERAPY CONTAINING BLEOMYCIN [J].
TALCOTT, JA ;
GARNICK, MB ;
STOMPER, PC ;
GODLESKI, JJ ;
RICHIE, JP .
JOURNAL OF UROLOGY, 1987, 138 (03) :619-620
[26]  
TASKINEN E, 1977, ACTA PATH MICRO IM A, V85, P713
[27]  
van den B, 1997, RESPIRATION, V64, P114
[28]  
Wirk B, 2010, CLIN MED INSIGHT-CAS, V3, P21