Sulforaphane exerts neuroprotective effects via suppression of the inflammatory response in a rat model of focal cerebral ischemia

被引：1
作者：
Ma, Li-Li [1 ]
Xing, Guo-Ping [2 ]
Yu, Yin [3 ]
Liang, Hui [1 ]
Yu, Tian-Xia [1 ]
Zheng, Wei-Hong [4 ]
Lai, Tian-Bao [4 ]
机构：
[1] Yantaishan Hosp, Dept Neurol, Yantai 264000, Peoples R China
[2] Weifang Peoples Hosp, Dept Neurol, Weifang 261599, Peoples R China
[3] Jilin Univ, China Japan Union Hosp, Hosp 3, Dept Neurosurg, Changchun 130033, Peoples R China
[4] Xiamen Univ, Zhongshan Hosp, Dept Neurol, Xiamen 361004, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2015年 / 8卷 / 10期
关键词：
Sulforaphane; inflammatory response; focal cerebral ischemia; NECROSIS-FACTOR-ALPHA; TNF-ALPHA; BRAIN; EXPRESSION; IL-1-BETA; PROTECTS; STROKE;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Inflammatory damage plays an important role in cerebral ischemic pathogenesis and may represent a promising target for treatment. Sulforaphane exerts protective effects in a rat model of focal cerebral ischemia/reperfusion injury by alleviating brain edema. However, the possible mechanisms of sulforaphane after cerebral ischemia/reperfusion injury have not been fully elucidated. Therefore, in the present study, we investigated the effect of sulforaphane on inflammatory reaction and the potential molecular mechanisms in cerebral ischemia rats. We found that sulforaphane significantly attenuated the blood-brain barrier (BBB) disruption; decreased the levels of pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 beta; reduced the nitric oxide (NO) levels and inducible nitric oxide synthase (iNOS) activity; inhibited the expression of iNOS and cyclooxygenase-2 (COX-2). In addition, sulforaphane inhibits the expression of p-NF-kappa B p65 after focal cerebral ischemia-reperfusion injury. Taken together, our results suggest that sulforaphane suppresses the inflammatory response via inhibiting the NF-kappa B signaling pathway in a rat model of focal cerebral ischemia, and sulforaphane may be a potential therapeutic agent for the treatment of cerebral ischemia injury.
引用
收藏
页码：17811 / 17817
页数：7
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