Enantioselective allylation of ketone-derived benzoylhydrazones: Practical synthesis of tertiary carbinarnines

被引：113

作者：

Berger, R ^{[1
]}

Duff, K ^{[1
]}

Leighton, JL ^{[1
]}

机构：

[1] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 18期

关键词：

D O I：

10.1021/ja0486418

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly practical method for the enantioselective allylation of ketone-derived benzoylhydrazones has been developed. The previously reported strained silacycle reagent 1 reacts with a wide variety of benzoylhydrazones to give the hydrazide products with good to excellent enantioselectivity (84-97% ee). A mechanism in which the acylhydrazone becomes caovalently attached to the silane has been established. Copyright © 2003 American Chemical Society.

引用

页码：5686 / 5687

页数：2

共 19 条

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