Thymic stromal lymphopoietin is expressed in the intact central nervous system and upregulated in the myelin-degenerative central nervous system

被引：13

作者：

Kitic, Maja ^{[1
]}

Wimmer, Isabella ^{[1
]}

Adzemovic, Milena ^{[1
]}

Koegl, Nikolaus ^{[1
]}

Rudel, Antonia ^{[1
]}

Lassmann, Hans ^{[1
]}

Bradl, Monika ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Neuroimmunol, Ctr Brain Res, A-1090 Vienna, Austria

来源：

GLIA | 2014年 / 62卷 / 07期

基金：

奥地利科学基金会;

关键词：

microglia; astrocytes; myelin degeneration; thymic stromal lymphopoietin; BRAIN DENDRITIC CELLS; REGIONAL HETEROGENEITY; CHOROID-PLEXUS; MICROGLIA; MACROPHAGES; PHENOTYPE; TSLP; INFILTRATION; INFLAMMATION; DIVERSITY;

D O I：

10.1002/glia.22662

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Thymic stromal lymphopoietin (TSLP) is an epithelial cytokine expressed at barrier surfaces of the skin, gut, nose, lung, and the maternal/fetal interphase. At these sites, it is important for the generation and maintenance of non-inflammatory, tissue-resident dendritic cell responses. We show here that TSLP is also expressed in the central nervous system (CNS) where it is produced by choroid plexus epithelial cells and astrocytes in the spinal cord. Under conditions of low-grade myelin degeneration, the numbers of TSLP-expressing astrocytes increase, and microglia express transcripts for the functional TSLP receptor dimer indicating that these cells are targets for TSLP in the myelin-degenerative CNS. GLIA 2014;62:1066-1074

引用

页码：1066 / 1074

页数：9

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