Mn-Catalyzed Electrochemical Synthesis of Quinazolinones from Primary Alcohols/Benzyl Ethers and o-Aminobenzamides

被引：40
作者：
Lin, Dian-Zhao [1 ]
Lai, Yin-Long [1 ]
Huang, Jing-Mei [1 ]
机构：
[1] South China Univ Technol, Key Lab Funct Mol Engn Guangdong Prov, Sch Chem & Chem Engn, Guangzhou 510640, Guangdong, Peoples R China
来源：
CHEMELECTROCHEM | 2019年 / 6卷 / 16期
基金：
中国国家自然科学基金;
关键词：
electrochemistry; manganese; quinazolinones; redox catalysts; synthetic methods; BUILDING ADDRESSABLE LIBRARIES; C-H FUNCTIONALIZATION; ONE-POT SYNTHESIS; AEROBIC OXIDATIVE SYNTHESIS; CASCADE SYNTHESIS; ANODIC-OXIDATION; BENZYL ALCOHOLS; QUINAZOLIN-4(3H)-ONES; ALDEHYDES; WATER;
D O I：
10.1002/celc.201801502
中图分类号：
O646 [电化学、电解、磁化学];
学科分类号：
081704 ;
摘要：
An efficient approach for the synthesis of quinazolinones from o-aminobenzamides and alcohols by the combination of electrochemistry and redox-metal catalysis has been developed. Taking manganese(II) sulfate as a redox catalyst, this transformation proceeded smoothly under ambient conditions in an undivided cell to afford quinazolinones in moderate to excellent yields with a wide substrate scope. Benzyl ethers were also suitable participants in the cascade cyclization sequence.
引用
收藏
页码：4188 / 4193
页数：6
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