Increased levels of serum and tissue miR-107 in human gastric cancer: Correlation with tumor hypoxia

被引：34

作者：

Ayremlou, Nooshin ^{[1
]}

Mozdarani, Hossein ^{[1
]}

Mowla, Seyed Javad ^{[2
]}

Delavari, Alireza ^{[3
]}

机构：

[1] Tarbiat Modares Univ, Dept Med Genet, Fac Med Sci, Tehran, Iran

[2] Tarbiat Modares Univ, Fac Biol Sci, Dept Mol Genet, Tehran, Iran

[3] Univ Tehran Med Sci, Shariati Hosp, Digest Dis Res Ctr, Tehran, Iran

来源：

CANCER BIOMARKERS | 2015年 / 15卷 / 06期

关键词：

Gastric cancer; miR-107; hypoxia; MICRORNA EXPRESSION PATTERNS; CIRCULATING MICRORNAS; HEPATOCELLULAR-CARCINOMA; PROGNOSTIC-SIGNIFICANCE; SOLID TUMORS; MARKERS; PROLIFERATION; DEREGULATION; METASTASIS; BIOMARKERS;

D O I：

10.3233/CBM-150529

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BACKGROUND: MicroRNAs can function as oncogenes and tumor suppressor genes in human cancers. The expression of miR-107 is high in various types of solid tumors. OBJECTIVE: The aim of this study was to evaluate the tumor and serum level of miR-107 and its correlation to HIF-1 alpha expression in gastric cancer patients. METHODS: Quantitative real-time PCR was used to analyze the expression of miR-107 and HIF-1a in 36 pairs of fresh gastric cancer and matched adjacent normal tissue specimens and the serum of these patients compared to age matched controls. RESULTS: The expression level of miR-107 was significantly higher in tumor tissues compared to adjacent normal tissue (p = 0.04). For serum, the expression level of miR-107 was significantly higher in gastric cancer patients than in age matched controls (p = 0.04). The correlation between tumor and serum expression of miR-107 with tumor hypoxia was found to be significant (p <= 0.001). CONCLUSION: The overexpression of miR-107 in tumors and serum of gastric cancer patients and its correlation with HIF-1a expression in tumor tissues was indicated that miR-107 may have a potential to use as a biomarker for detection of gastric cancer patients and hypoxia in gastric cancer tumor.

引用

页码：851 / 860

页数：10

共 55 条

[1] Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma [J].

Arroyo, Jason D. ;

Chevillet, John R. ;

Kroh, Evan M. ;

Ruf, Ingrid K. ;

Pritchard, Colin C. ;

Gibson, Donald F. ;

Mitchell, Patrick S. ;

Bennett, Christopher F. ;

Pogosova-Agadjanyan, Era L. ;

Stirewalt, Derek L. ;

Tait, Jonathan F. ;

Tewari, Muneesh .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (12) :5003-5008

[2] Circulating MicroRNAs: Molecular Microsensors in Gastrointestinal Cancer [J].

Blanco-Calvo, Moises ;

Calvo, Lourdes ;

Figueroa, Angelica ;

Haz-Conde, Mar ;

Anton-Aparicio, Luis ;

Valladares-Ayerbes, Manuel .

SENSORS, 2012, 12 (07) :9349-9362

[3] MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype [J].

Blenkiron, Cherie ;

Goldstein, Leonard D. ;

Thorne, Natalie P. ;

Spiteri, Inmaculada ;

Chin, Suet-Feung ;

Dunning, Mark J. ;

Barbosa-Morais, Nuno L. ;

Teschendorff, Andrew E. ;

Green, Andrew R. ;

Ellis, Ian O. ;

Tavare, Simon ;

Caldas, Carlos ;

Miska, Eric A. .

GENOME BIOLOGY, 2007, 8 (10)

[4] MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis [J].

Bloomston, Mark ;

Frankel, Wendy L. ;

Petrocca, Fabio ;

Volinia, Stefano ;

Alder, Hansjuerg ;

Hagan, John P. ;

Liu, Chang-Gong ;

Bhatt, Darshna ;

Taccioli, Cristian ;

Croce, Carlo M. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 297 (17) :1901-1908

[5]

Brown JM, 1998, CANCER RES, V58, P1408

[6] Changes in circulating microRNA levels associated with prostate cancer [J].

Bryant, R. J. ;

Pawlowski, T. ;

Catto, J. W. F. ;

Marsden, G. ;

Vessella, R. L. ;

Rhees, B. ;

Kuslich, C. ;

Visakorpi, T. ;

Hamdy, F. C. .

BRITISH JOURNAL OF CANCER, 2012, 106 (04) :768-774

[7] MicroRNAs and cell cycle regulation [J].

Carleton, Michael ;

Cleary, Michele A. ;

Linsley, Peter S. .

CELL CYCLE, 2007, 6 (17) :2127-2132

[8] miR-103/107 Promote Metastasis of Colorectal Cancer by Targeting the Metastasis Suppressors DAPK and KLF4 [J].

Chen, Hsin-Yi ;

Lin, Yu-Min ;

Chung, Hsiang-Ching ;

Lang, Yaw-Dong ;

Lin, Ching-Jung ;

Huang, John ;

Wang, Wei-Chi ;

Lin, Feng-Mao ;

Chen, Zhen ;

Huang, Hsien-Da ;

Shyy, John Y. -J. ;

Liang, Jin-Tung ;

Chen, Ruey-Hwa .

CANCER RESEARCH, 2012, 72 (14) :3631-3641

[9] miR-107 promotes tumor progression by targeting the let-7 microRNA in mice and humans [J].

Chen, Pai-Sheng ;

Su, Jen-Liang ;

Cha, Shih-Ting ;

Tarn, Woan-Yuh ;

Wang, Ming-Yang ;

Hsu, Hsing-Chih ;

Lin, Ming-Tsan ;

Chu, Chia-Yu ;

Hua, Kuo-Tai ;

Chen, Chiung-Nien ;

Kuo, Tsang-Chih ;

Chang, King-Jen ;

Hsiao, Michael ;

Chang, Yi-Wen ;

Chen, Jin-Shing ;

Yang, Pan-Chyr ;

Kuo, Min-Liang .

JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (09) :3442-3455

[10] Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases [J].

Chen, Xi ;

Ba, Yi ;

Ma, Lijia ;

Cai, Xing ;

Yin, Yuan ;

Wang, Kehui ;

Guo, Jigang ;

Zhang, Yujing ;

Chen, Jiangning ;

Guo, Xing ;

Li, Qibin ;

Li, Xiaoying ;

Wang, Wenjing ;

Zhang, Yan ;

Wang, Jin ;

Jiang, Xueyuan ;

Xiang, Yang ;

Xu, Chen ;

Zheng, Pingping ;

Zhang, Juanbin ;

Li, Ruiqiang ;

Zhang, Hongjie ;

Shang, Xiaobin ;

Gong, Ting ;

Ning, Guang ;

Wang, Jun ;

Zen, Ke ;

Zhang, Junfeng ;

Zhang, Chen-Yu .

CELL RESEARCH, 2008, 18 (10) :997-1006

← 1 2 3 4 5 6 →