A tethered aminohydroxylation route to L-arabino-[2R,3S,4R] and L-xylo-[2R,3S,4S]-C18-phytosphingosines

被引：19
|
作者：
Dubey, Abhishek [1 ]
Kumar, Pradeep [1 ]
机构：
[1] Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 26期
关键词：
Sharpless asymmetric kinetic resolution; Tethered aminohydroxylation; Regioselectivity; Stereoselectivity; Phytosphingosine; Sphingolipids; EFFICIENT TOTAL-SYNTHESIS; ASYMMETRIC-SYNTHESIS; ALLYLIC ALCOHOLS; PHYTOSPHINGOSINE; SPHINGOLIPIDS; CERAMIDES; MUCOSA; TA;
D O I：
10.1016/j.tetlet.2009.02.173
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A concise and highly efficient synthesis of L-arabino-[2R,3S,4R] and L-xylo-[ 2R,3S,4S]-C-18-phytosphingosines has been achieved. The synthetic strategy features the Sharpless kinetic resolution and tethered aminohydroxylation as the key steps. (C) 2009 Elsevier Ltd, All rights reserved.
引用
收藏
页码：3425 / 3427
页数：3
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