Catalytic Enantioselective Total Synthesis of (-)-Pyridovericin

被引：4

作者：

Schmid, Fabian ^{[1
]}

Bernasconi, Maurizio ^{[1
]}

Jessen, Henning J. ^{[1
]}

Pfaltz, Andreas ^{[1
]}

Gademann, Karl ^{[1
]}

机构：

[1] Univ Basel, Dept Chem, CH-4056 Basel, Switzerland

来源：

SYNTHESIS-STUTTGART | 2014年 / 46卷 / 07期

基金：

瑞士国家科学基金会;

关键词：

pyridovericin; total synthesis; natural products; hydrogenation; asymmetric catalysis; PYRIDONE ALKALOIDS; PYRIDOVERICIN; ACIDS;

D O I：

10.1055/s-0033-1340868

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first enantioselective catalytic total synthesis of (-)-pyridovericin is reported. The key steps involve a modified HWE reaction under aqueous conditions and an asymmetric iridium-catalyzed hydrogenation. This resulted in a highly modular and stereoselective approach that delivered the target natural product in high yield and stereoselectivity.

引用

收藏

页码：864 / 870

页数：7

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