Mapping quantitative trait loci for the lysozyme level and immunoglobulin G blocking percentage of classical swine fever virus

被引：3
作者：
Lu, X. [1 ,2 ]
Gong, Y. F. [1 ,3 ]
Liu, J. F. [1 ]
Liu, Y. [1 ]
Zhang, Q. [1 ]
机构：
[1] China Agr Univ, Coll Anim Sci & Technol, Key Lab Anim Genet & Breeding, Minist Agr,State Key Lab AgroBiotechnol, Beijing 100094, Peoples R China
[2] Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, Collaborat Innovat Ctr Diag & Treatment Infect Di, State Key Lab Infect Dis Prevent & Control, Beijing, Peoples R China
[3] Hebei Normal Univ Sci & Technol, Dept Anim Sci, Changli, Hebei, Peoples R China
来源：
GENETICS AND MOLECULAR RESEARCH | 2014年 / 13卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Lysozyme; Immunoglobulin G; Quantitative trait loci; Classical swine fever; Swine; RESIDUAL MAXIMUM-LIKELIHOOD; OUTCROSS POPULATIONS; T-LYMPHOCYTES; INHIBITOR; INFECTION; NUMBERS; ANTIGEN; SYSTEM; GROWTH; CELLS;
D O I：
10.4238/2014.January.17.13
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Increased disease resistance through improved general immune capacity would be beneficial for the welfare and productivity of farm animals. Classical swine fever (CSF) is a contagious disease in farm animals. The immunoglobulin G (IgG) blocking percentage of CSF virus (CSFV) in serum is an essential diagnostic parameter in veterinary practice. In addition, lysozymes are a part of the innate immune system. To identify quantitative trait loci (QTL) for IgG blocking percentage of CSFV and lysozyme concentration, IgG blocking percentage and lysozyme concentration in serum were measured in a composite pig population before and after challenge with modified live CSF vaccine. Through genome-wide mapping by MQREML analysis and the SOLAR software, several QTL for the lysozyme concentration and the IgG blocking percentage of CSFV were identified, respectively. Within these QTL regions, some known genes were revealed, and some of them may serve as candidate genes in the pig.
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收藏
页码：283 / 290
页数：8
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