Neutrophil microparticles modulate cytokine production by natural killer cells

被引：41

作者：

Pliyev, Boris K. ^{[1
]}

Kalintseva, Mariya V. ^{[1
]}

Abdulaeva, Sofya V. ^{[2
]}

Yarygin, Konstantin N. ^{[2
]}

Savchenko, Valery G. ^{[1
]}

机构：

[1] Hematol Res Ctr, Moscow 125167, Russia

[2] Inst Biomed Chem, Moscow 119121, Russia

来源：

CYTOKINE | 2014年 / 65卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

Neutrophil microparticles; NK cells; Cytokines; Phosphatidylserine; ECTOSOMES; IMMUNITY; RELEASE;

D O I：

10.1016/j.cyto.2013.11.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neutrophil microparticles (NMs) are scarce in the circulation but are highly enriched at sites of inflammation and exert profound effects on immune cells. In the present study, we addressed whether NMs modulate cytokine-producing capacity of natural killer (NK) cells. NMs inhibited the production of IFN-gamma and TNF-alpha but enhanced the release of TGF-beta 1 by IL-2/IL-12-activated NK cells. The inhibitory effect of NMs was strongly attenuated by blockade of phosphatidylserine exposed on NMs. Thus, NMs skew the cytokine profile of NK cells from pro-inflammatory toward anti-inflammatory, potentially favoring the resolution of inflammation. (C) 2013 Elsevier Ltd. All rights reserved.

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收藏

页码：126 / 129

页数：4

相关论文

共 11 条

[1] Synovial microparticles from arthritic patients modulate chemokine and cytokine release by synoviocytes [J].

Berckmans, RJ ;

Nieuwland, R ;

Kraan, MC ;

Schaap, MCL ;

Pots, D ;

Smeets, TJM ;

Sturk, A ;

Tak, PP .

ARTHRITIS RESEARCH & THERAPY, 2005, 7 (03) :R536-R544

[2] In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant [J].

Combes, V ;

Simon, AC ;

Grau, GE ;

Arnoux, D ;

Camoin, L ;

Sabatier, F ;

Mutin, M ;

Sanmarco, M ;

Sampol, J ;

Dignat-George, F .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (01) :93-102

[3] The defensive alliance between neutrophils and NK cells as a novel arm of innate immunity [J].

Costantini, Claudio ;

Cassatella, Marco A. .

JOURNAL OF LEUKOCYTE BIOLOGY, 2011, 89 (02) :221-233

[4] Polymorphonuclear neutrophil-derived ectosomes interfere with the maturation of monocyte-derived dendritic cells [J].

Eken, Ceylan ;

Gasser, Olivier ;

Zenhaeusern, Gabriela ;

Oehri, Ineke ;

Hess, Christoph ;

Schifferli, Juerg A. .

JOURNAL OF IMMUNOLOGY, 2008, 180 (02) :817-824

[5] Activated polymorphonuclear neutrophils disseminate anti-inflammatory microparticles by ectocytosis [J].

Gasser, O ;

Schifferli, JA .

BLOOD, 2004, 104 (08) :2543-2548

[6] Anti-Neutrophil Cytoplasmic Antibodies Stimulate Release of Neutrophil Microparticles [J].

Hong, Ying ;

Eleftheriou, Despina ;

Hussain, Abdullah A. K. ;

Price-Kuehne, Fiona E. ;

Savage, Caroline O. ;

Jayne, David ;

Little, Mark A. ;

Salama, Alan D. ;

Klein, Nigel J. ;

Brogan, Paul A. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2012, 23 (01) :49-62

[7]

Mesri C, 1998, J IMMUNOL, V161, P4382

[8] Participation of the urokinase-type plasminogen activator receptor (uPAR) in neutrophil transendothelial migration [J].

Pliyev, Boris K. ;

Antonova, Olga A. ;

Menshikov, Mikhail .

MOLECULAR IMMUNOLOGY, 2011, 48 (9-10) :1168-1177

[9] Human microparticles generated during sepsis in patients with critical illness are neutrophil-derived and modulate the immune response [J].

Prakash, Priya S. ;

Caldwell, Charles C. ;

Lentsch, Alex B. ;

Pritts, Timothy A. ;

Robinson, Bryce R. H. .

JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 2012, 73 (02) :401-406

[10] Ectosomes as modulators of inflammation and immunity [J].

Sadallah, S. ;

Eken, C. ;

Schifferli, J. A. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2011, 163 (01) :26-32