Characterization of a selective inhibitor for matrix metalloproteinase-8 (MMP-8)

被引：10

作者：

Ding, Derong ^{[1
]}

Lichtenwalter, Katerina ^{[1
]}

Pi, Hualiang ^{[1
]}

Mobashery, Shahriar ^{[1
]}

Chang, Mayland ^{[1
]}

机构：

[1] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA

来源：

MEDCHEMCOMM | 2014年 / 5卷 / 09期

关键词：

MODULATORS; EXPRESSION; ROLES; NMR;

D O I：

10.1039/c4md00172a

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MMP-8 has been implicated in various diseases. Selective MMP-8 inhibitors are needed to ascertain the role of this enzyme. We synthesized two inhibitors reported previously as selective for MMP-8. Compound 1 selectively inhibited MMP-8 and MMP-13; compound 2 was a potent broad-spectrum inhibitor, notwithstanding that it is used as a selective one.

引用

页码：1381 / 1383

页数：3

共 50 条

[31] Matrix metalloproteinase-8 activity in gingival crevicular fluid: development of a novel assay
Mc Crudden, M. T. C.
Irwin, C. R.
El Karim, I.
Linden, G. J.
Lundy, F. T.
JOURNAL OF PERIODONTAL RESEARCH, 2017, 52 (03) : 556 - 561
[32] Active-Matrix Metalloproteinase-8, Myeloperoxidase in Relation With Periodontics, Preterm Birth
Alan, Murat
Sorsa, Timo
Kantar, Pinar Meric
Raisanen, Ismo T.
Gurlek, Onder
Kanmaz, Burcu
Buduneli, Nurcan
ORAL DISEASES, 2024, : 1333 - 1341
[33] Targeted Inhibition of Matrix Metalloproteinase-8 Prevents Aortic Dissection in a Murine Model
Zhang, Chengxin
Niu, Kaiyuan
Ren, Meixia
Zhou, Xinmiao
Yang, Zhisheng
Yang, Mei
Wang, Xinxin
Luo, Jun
Shao, Yue
Zhang, Cheng
Chen, Dan
Gao, Shan
Ge, Shenglin
Wu, Qingchen
Xiao, Qingzhong
CELLS, 2022, 11 (20)
[34] Effects of Inhaled Corticosteroids on Metalloproteinase-8 and Tissue Inhibitor of Metalloproteinase-1 in the Airways of Asthmatic Children
Obase, Y.
Rytila, P.
Metso, T.
Pelkonen, A. S.
Tervahartiala, T.
Turpeinen, M.
Makela, M.
Saarialho-Kere, U.
Selroos, O.
Sorsa, T.
Haahtela, T.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2010, 151 (03) : 247 - 254
[35] The Measurement of Circulating Matrix Metalloproteinase-8 and its Tissue Inhibitor and their Association with Inflammatory Mediators in Patients with Acute Coronary Syndrome
Allal-Elasmi, Monia
Zayani, Yosra
Zidi, Wiem
Zaroui, Amira
Feki, Moncef
Mourali, Sami
Mechmeche, Rachid
Kaabachi, Naziha
CLINICAL LABORATORY, 2014, 60 (06) : 951 - 956
[36] Salivary Interleukin-6, Matrix Metalloproteinase-8, and Osteoprotegerin in Patients With Periodontitis and Diabetes
Costa, Priscila P.
Trevisan, Glauce L.
Macedo, Guilherme O.
Palioto, Daniela B.
Souza, Sergio L. S.
Grisi, Marcio F. M.
Novaes, Arthur B., Jr.
Taba, Mario, Jr.
JOURNAL OF PERIODONTOLOGY, 2010, 81 (03) : 384 - 391
[37] Healing of extraction sockets in collagenase-2 (matrix metalloproteinase-8)-deficient mice
Korpi, Jarkko T.
Astrom, Pirjo
Lehtonen, Niko
Tjaderhane, Leo
Kallio-Pulkkinen, Soili
Siponen, Maria
Sorsa, Timo
Pirila, Emma
Salo, Tuula
EUROPEAN JOURNAL OF ORAL SCIENCES, 2009, 117 (03) : 248 - 254
[38] Matrix Metalloproteinase-8 and the Regulation of Blood Pressure, Vascular Inflammation, and Atherosclerotic Lesion Growth
Mallat, Ziad
CIRCULATION RESEARCH, 2009, 105 (09) : 827 - 829
[39] Matrix metalloproteinase-1 (MMP-1) and (MMP-8) gene polymorphisms promote increase and remodeling of the collagen III and V in posterior tibial tendinopathy
Diniz-Fernandes, Tulio
Godoy-Santos, Alexandre Leme
Santos, Maria Cristina
Pontin, Pedro
Alves Pereira, Caio Augusto
Jardim, Yuri Justi
Pereira Velosa, Ana Paula
Maffulli, Nicola
Teodoro, Walcy Rosolia
Capelozzi, Vera Luiza
HISTOLOGY AND HISTOPATHOLOGY, 2018, 33 (09) : 929 - 936
[40] Tissue Inhibitor of Metalloproteinase-1 Promotes Polymorphonuclear Neutrophil (PMN) Pericellular Proteolysis by Anchoring Matrix Metalloproteinase-8 and-9 to PMN Surfaces
Wang, Xiaoyun
Rojas-Quintero, Joselyn
Wilder, Julie
Tesfaigzi, Yohannes
Zhang, Duo
Owen, Caroline A.
JOURNAL OF IMMUNOLOGY, 2019, 202 (11) : 3267 - 3281

← 1 2 3 4 5 →