Characterization of a selective inhibitor for matrix metalloproteinase-8 (MMP-8)

被引：10

作者：

Ding, Derong ^{[1
]}

Lichtenwalter, Katerina ^{[1
]}

Pi, Hualiang ^{[1
]}

Mobashery, Shahriar ^{[1
]}

Chang, Mayland ^{[1
]}

机构：

[1] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA

来源：

MEDCHEMCOMM | 2014年 / 5卷 / 09期

关键词：

MODULATORS; EXPRESSION; ROLES; NMR;

D O I：

10.1039/c4md00172a

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MMP-8 has been implicated in various diseases. Selective MMP-8 inhibitors are needed to ascertain the role of this enzyme. We synthesized two inhibitors reported previously as selective for MMP-8. Compound 1 selectively inhibited MMP-8 and MMP-13; compound 2 was a potent broad-spectrum inhibitor, notwithstanding that it is used as a selective one.

引用

页码：1381 / 1383

页数：3

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