MRI compatible electrodes for the induction of amygdala kindling in rats

被引：13

作者：

Jupp, Bianca

Williams, John P.

Tesiram, Yasvir A.

Vosmansky, Milosh

O'Brien, Terence J. ^{[1
]}

机构：

[1] Univ Melbourne, Royal Melbourne Hosp, Dept Med, Parkville, Vic 3050, Australia

[2] Univ Melbourne, Howard Florey Inst Expt Physiol & Med, Parkville, Vic 3050, Australia

[3] Austin Hosp, Heidelberg, Vic 3084, Australia

来源：

JOURNAL OF NEUROSCIENCE METHODS | 2006年 / 155卷 / 01期

关键词：

temporal lobe epilepsy; kindling; MRI; electrodes;

D O I：

10.1016/j.jneumeth.2005.12.024

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The rat electrical kindling model has been widely utilized in epilepsy research. This study aimed to identify the optimum "MRI compatible" bipolar stimulating and recording electrodes to enable serial MRI acquisition in this model. Two types of custom-made electrodes (gold and carbon) were compared with commercial platinum-iridium alloy electrodes for suitability based on size, effect on image quality and kindling induction. The custom-made gold electrodes, based on these parameters, were found to be most suitable. These electrodes enable the study of epileptogenesis utilizing MRI in this model of temporal lobe epilepsy (TLE). (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：72 / 76

页数：5

共 22 条

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