Fatigue as the missing link between bone fragility and fracture

被引：63

作者：

Acevedo, Claire ^{[1
,2
,3
]}

Stadelmann, Vincent A. ^{[4
,5
]}

Pioletti, Dominique P. ^{[6
]}

Alliston, Tamara ^{[1
]}

Ritchie, Robert O. ^{[2
,7
]}

机构：

[1] Univ Calif San Francisco, Dept Orthopaed Surg, San Francisco, CA 94131 USA

[2] Lawrence Berkeley Natl Lab, Mat Sci Div, Berkeley, CA 94720 USA

[3] Univ Utah, Dept Mech Engn, Salt Lake City, UT 84112 USA

[4] AO Res Inst Davos, Davos Pl, Davos, Switzerland

[5] SCANCO Med AG, Bruettisellen, Switzerland

[6] Ecole Polytech Fed Lausanne, Swiss Fed Inst Technol Lausanne, Inst Bioengn, Lab Biomech Orthoped, Lausanne, Switzerland

[7] Univ Calif Berkeley, Dept Mat Sci & Engn, Berkeley, CA 94720 USA

来源：

NATURE BIOMEDICAL ENGINEERING | 2018年 / 2卷 / 02期

基金：

瑞士国家科学基金会;

关键词：

HUMAN CORTICAL BONE; AGE-RELATED-CHANGES; GLYCATION END-PRODUCTS; SACRAL INSUFFICIENCY FRACTURES; REFERENCE-POINT INDENTATION; OSTEOCYTE LACUNAR DENSITY; IN-VITRO FATIGUE; MECHANICAL-PROPERTIES; STRESS-FRACTURE; NONENZYMATIC GLYCATION;

D O I：

10.1038/s41551-017-0183-9

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The prevention of fragility fractures in bone-pathologic fractures resulting from daily activity and mostly occurring in the elderly population-has been a long-term clinical quest. Recent research indicating that falls in the elderly might be the consequence of fracture rather than its cause has raised fundamental questions about the origin of fragility fractures. Is day-to-day cyclic loading, instead of a single-load event such as a fall, the main cause of progressively growing fractures? Are fragility fractures predominantly affected by bone quality rather than bone mass, which is the clinical indicator of fracture risk? Do osteocytes actively participate in the bone repair process? In this Perspective, we discuss the central role of cyclic fatigue in bone fragility fracture.

引用

页码：62 / 71

页数：10

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