Immunotherapy for Head and Neck Squamous Cell Carcinoma

被引：30

作者：

Schoppy, David W. ^{[1
]}

Sunwoo, John B. ^{[1
]}

机构：

[1] Stanford Univ, Div Head & Neck Surg, Dept Otolaryngol, Sch Med, Stanford, CA 94305 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2015年 / 29卷 / 06期

关键词：

HNSCC; Immunotherapy; CTLA-4; PD-1; Cetuximab; Vaccine; Chimeric antigen receptor; SEQUENCE P53(264-272) PEPTIDE; RECEPTOR T-CELLS; ANTI-PD-L1; ANTIBODY; CANCER-PATIENTS; NATURAL-KILLER; PLUS CETUXIMAB; RECURRENT HEAD; CD137; PEMBROLIZUMAB; CYTOTOXICITY;

D O I：

10.1016/j.hoc.2015.07.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although head and neck squamous cell carcinoma has traditionally been considered to be a very immunosuppressive, or at least nonimmunogenic, tumor type, recent results from clinical studies of immune checkpoint blockade strategies have led to resurgence in the enthusiasm for immunotherapeutic approaches. Additional strategies for immunotherapy that are under active investigation include enhancement of cetuximab-mediated antibody-dependent cell-mediated cytotoxicity, tumor vaccines, and engineered T cells for adoptive therapy. All of these studies have early-phase clinical trials under way, and the next several years will be exciting as the results of these studies are reported.

引用

页码：1033 / +

页数：12

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