Mesenchymal Stem Cells in the Treatment of Amyotrophic Lateral Sclerosis

被引：21
作者：
Hajivalili, Mahsa [1 ,2 ]
Pourgholi, Fatemeh [1 ,2 ]
Kafil, Hossein Samadi [3 ]
Jadidi-Niaragh, Farhad [1 ,2 ,4 ]
Yousefi, Mehdi [1 ,2 ,3 ]
机构：
[1] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran
[2] Tabriz Univ Med Sci, Fac Med, Dept Immunol, Tabriz, Iran
[3] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran
[4] Univ Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Tehran, Iran
来源：
CURRENT STEM CELL RESEARCH & THERAPY | 2016年 / 11卷 / 01期
关键词：
Amyotrophic lateral sclerosis; mesenchymal stem cells; stem cell; treatment; MARROW STROMAL CELLS; HUMAN ADIPOSE-TISSUE; RAT MODEL; DISEASE PROGRESSION; GROWTH-FACTORS; MOUSE MODEL; TRANSPLANTATION; ALS; BRAIN; DELIVERY;
D O I：
10.2174/1574888X10666150902095031
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder which is characterized by motor neuron (MN) dysfunction, progressive paralysis, and death. Although several therapeutic approaches have been used for treatment of ALS, little success has been achieved. Natural vectors such as mesenchymal stem cells (MSCs) can be a promising tool for overcoming therapeutic problems. MSCs have multipotential characteristics such as the ability to differentiate into variety of cell types, easy access, immunomodulation, tissue repair, exertion of trophic factors, exosome secretion and efficient homing. In this review, we will discuss the characteristics of MSCs and their possible therapeutic mechanisms in ALS patients.
引用
收藏
页码：41 / 50
页数：10
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