New Perspectives on Antimicrobial Agents: Remdesivir Treatment for COVID-19

被引：50
作者：
Aleissa, Muneerah M. [1 ]
Silverman, Emily A. [2 ,3 ]
Acosta, Luisa M. Paredes [4 ,5 ]
Nutt, Cameron T. [4 ,5 ]
Richterman, Aaron [6 ]
Marty, Francisco M. [2 ,3 ,4 ,5 ]
机构：
[1] Brigham & Womens Hosp, Dept Pharm, 75 Francis St, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, Div Infect Dis, 75 Francis St, Boston, MA 02115 USA
[3] Dana Farber Canc Inst, Boston, MA 02115 USA
[4] Brigham & Womens Hosp, Dept Med, 75 Francis St, Boston, MA 02115 USA
[5] Harvard Med Sch, Boston, MA 02115 USA
[6] Hosp Univ Penn, Div Infect Dis, Philadelphia, PA 19104 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2021年 / 65卷 / 01期
关键词：
remdesivir; antiviral; COVID-19; SARS-CoV-2; EBOLA-VIRUS; CORONAVIRUS; GS-5734; MODEL;
D O I：
10.1128/AAC.01814-20
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Remdesivir was recently approved by the Food and Drug Administration for the treatment of hospitalized patients with coronavirus disease 2019 (COVID-19). Remdesivir is the prodrug of an adenosine analogue that inhibits viral replication of several RNA virus families, including Coronaviridae. Preclinical data in animal models of coronavirus diseases, including COVID-19, have demonstrated that early treatment with remdesivir leads to improved survival, decreased lung injury, and decreased levels of viral RNA. Recent clinical data have demonstrated the clinical activity of remdesivir in terms of faster time to recovery in patients with severe COVID-19 and higher odds of improved clinical status in patients with moderate COVID-19. Here, clinical trials published to date are presented and appraised. Remdesivir's potential benefits and its favorable adverse-event profile make it an option for the treatment of COVID-19. This article examines the available literature describing remdesivir's pharmacology, pharmacokinetics, and preclinical and clinical data.
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页数：18
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