Secondary metabolites from Lantana camara L. flowers extract exhibit in vivo anti-urolithiatic activity in adult Wistar albino rats

被引：7
|
作者：
Ezzat, Marwa I. [1 ]
El Gendy, Salsabeel N. [1 ]
Saad, Ahmed S. [2 ]
Abdo, Walied S. [3 ]
EL Sayed, Aly M. [1 ]
Elmotayam, Amira K. [1 ]
机构：
[1] Cairo Univ, Fac Pharm, Pharmacognosy Dept, Cairo, Egypt
[2] Port Said Univ, Fac Pharm, Dept Pharmacol & Toxicol, Port Said, Egypt
[3] Kaferelsheik Univ, Fac Vet Med, Dept Pathol, Kafrelsheikh, Egypt
来源：
NATURAL PRODUCT RESEARCH | 2020年 / 36卷 / 04期
关键词：
Lantana camara L; HPLC-PDA-MS; MS; flavonoids; phenylethanoids; ethylene glycol; antiurolithiatic;
D O I：
10.1080/14786419.2020.1853726
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The present study aims at evaluating potential of the ethanol extracts of L. camara leaves (LE), flowers (FlE) and roots (RE) in the treatment of renal calculi and characterising the secondary metabolites in the active extract. The results revealed that the FlE had significantly reduced the levels of kidney parameters (calcium, creatinine, urea, and uric acid) against ethylene glycol (EG) injuries, and restored the activity of glutathione peroxidase (GPx), superoxide dismutase and lipid peroxide malondialdehyde to the normal level. In addition, FlE significantly attenuated iNOS tissue expression caused by EG. The results obtained in this study suggest the potential value of the L. camara L. flowers as an antiurolithiatic agent.
引用
收藏
页码：1115 / 1117
页数：3
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