Electrochemical synthesis of reduced graphene oxide/ruthenium oxide hexacyanoferrate nanocomposite film and its application for ranitidine detection

Here we describe a simple and rapid voltammetric fabrication of a novel nanocomposite modified glassy carbon electrode (GCE) based on reduced graphene oxide/ruthenium oxide hexacyanoferrate (rGO/RuOHCF). The performance of the electrode was tested for ranitidine (RTD) electrocatalytic oxidation. Characterization techniques confirmed an efficient electrochemical reduction of graphene oxide (GO) and the formation of ruthenium oxide hexacyanoferrate (RuOHCF) nanoparticles. The nanocomposite presented well distributed similar to 89 nm particles entrenched in wrinkled graphene sheets. The electrochemical behavior of RTD on the nanocomposite surface was examined by cyclic voltammetry, and its mass transport process was evaluated by scan rate test. The parameters of the amperometry with batch-injection analysis (BIA) system for RTD determination were optimized, and the calibration curve presented high linearity (R-2= 0.999) from5.0 to 100.0 mu mol L-1, good sensitivity of 0.216 mu AL mu mol(-1), and a limit of detection (LD) of 274.4 nmol L-1. RTD from pharmacological samples was successfully determined, with approximately 95% of recovery.