Induction of the MCP chemokine cluster cascade in the periphery by cancer cell-derived Cc13

被引：22

作者：

Farmaki, Elena ^{[1
]}

Kaza, Vimala ^{[1
]}

Papavassiliou, Athanasios G. ^{[2
]}

Chatzistamou, Ioulia ^{[3
]}

Kiaris, Hippokratis ^{[1
,2
,4
]}

机构：

[1] Univ South Carolina, Dept Drug Discovery & Biomed Sci, CLS 713,715 Sumter St, Columbia, SC 29208 USA

[2] Natl & Kapodistrian Univ Athens, Sch Med, Dept Biol Chem, Athens 11527, Greece

[3] Univ South Carolina, Sch Med, Dept Pathol Microbiol & Immunol, Columbia, SC 29208 USA

[4] Univ South Carolina, Peromyscus Genet Stock Ctr, Columbia, SC 29208 USA

来源：

CANCER LETTERS | 2017年 / 389卷

关键词：

CCL3; Chemokine; Breast cancer; Inflammation; Periphery; Metastasis; BREAST-CANCER; METASTASIS; GROWTH; ACCUMULATION; EXPRESSION; RECEPTOR; GENES; CCL11;

D O I：

10.1016/j.canlet.2016.12.028

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The induction of localized pro-inflammatory niches in the periphery is instrumental in metastasis. In order to better understand how tumors engage distal sites and activate a pro-inflammatory response we utilized syngeneic breast cancers as a model and showed that soluble factors from the neoplastic epithelium activate the expression of the monocyte chemoattractive protein (MCP) chemokines of the mouse 11C cluster that include all, Cc12, Cc17, Cc18, Cclii and Cc112. Tissues such as the lungs and the brain, that are more prone to colonization by breast cancer cells, were more sensitive to MCP cluster chemokine induction than others such as the liver. Subsequent analyses involving chemokine arrays in breast cancer cells and media followed by functional validation assays in in vitro and in vivo identified the cytokine Cc13 as the principle mediator of the communication between the neoplastic epithelium and the peripheral tissues in terms of MCP cluster chemokine induction. Our results show that MCP chemokines are activated in peripheral tissues of breast cancer-bearing mice, by a mechanism that involves breast cancer cell-derived Cc13. Interference with the expression of cancer cell-derived Cc13 may find application in the management of breast cancer metastases. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：49 / 58

页数：10

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