Environmental Designer Drugs: When Transformation May Not Eliminate Risk

被引：73

作者：

Cwiertny, David M. ^{[1
]}

Snyder, Shane A. ^{[2
,3
]}

Schlenk, Daniel ^{[4
]}

Kolodziej, Edward P. ^{[5
,6
]}

机构：

[1] Univ Iowa, Seamans Ctr 4105, Iowa City, IA 52242 USA

[2] Univ Arizona, Tucson, AZ 85721 USA

[3] Natl Univ Singapore, NERI, Singapore 117411, Singapore

[4] Univ Calif Riverside, Dept Environm Sci, Riverside, CA 92521 USA

[5] Univ Washington, Tacoma, WA 98402 USA

[6] Univ Washington, Dept Civil & Environm Engn, Seattle, WA 98195 USA

来源：

ENVIRONMENTAL SCIENCE & TECHNOLOGY | 2014年 / 48卷 / 20期

基金：

美国国家科学基金会;

关键词：

WASTE-WATER EFFLUENTS; IN-VITRO; ESTROGENIC ACTIVITY; DISRUPTING ACTIVITY; AQUEOUS-SOLUTION; SURFACE-WATER; DEGRADATION; ANDROGENS; PRODUCTS; FATE;

D O I：

10.1021/es503425w

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Environmental transformation processes, including those occurring in natural and engineered systems, do not necessarily drastically alter molecular structures of bioactive organic contaminants. While the majority of generated transformation products are likely benign, substantial conservation of structure in transformation products can imply conservation or even creation of bioactivity across multiple biological end points and thus incomplete mitigation of ecological risk. Therefore, focusing solely on parent compound removal for contaminants of higher relative risk, the most common approach to fate characterization, provides no mechanistic relationship to potential biological effects and is inadequate as a comprehensive metric for reduction of ecological risks. Here, we explore these phenomena for endocrine-active steroid hormones, focusing on examples of conserved bioactivity and related implications for fate assessment, regulatory approaches, and research opportunities. © 2014 American Chemical Society.

引用

页码：11737 / 11745

页数：9

共 63 条

[1] Repeating history: Pharmaceuticals in the environment [J].

Ankley, Gerald T. ;

Brooks, Bryan W. ;

Huggett, Duane B. ;

Sumpter, John P. .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2007, 41 (24) :8211-8217

[2] ADVERSE OUTCOME PATHWAYS: A CONCEPTUAL FRAMEWORK TO SUPPORT ECOTOXICOLOGY RESEARCH AND RISK ASSESSMENT [J].

Ankley, Gerald T. ;

Bennett, Richard S. ;

Erickson, Russell J. ;

Hoff, Dale J. ;

Hornung, Michael W. ;

Johnson, Rodney D. ;

Mount, David R. ;

Nichols, John W. ;

Russom, Christine L. ;

Schmieder, Patricia K. ;

Serrrano, Jose A. ;

Tietge, Joseph E. ;

Villeneuve, Daniel L. .

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2010, 29 (03) :730-741

[3] Effects of the androgenic growth promoter 17-β-trenbolone on fecundity and reproductive endocrinology of the fathead minnow [J].

Ankley, GT ;

Jensen, KM ;

Makynen, EA ;

Kahl, MD ;

Korte, JJ ;

Hornung, MW ;

Henry, TR ;

Denny, JS ;

Leino, RL ;

Wilson, VS ;

Cardon, MC ;

Hartig, PC ;

Gray, LE .

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2003, 22 (06) :1350-1360

[4] Using Electronic Theory To Identify Metabolites Present in 17α-Ethinylestradiol Biotransformation Pathways [J].

Barr, William J. ;

Yi, Taewoo ;

Aga, Diana ;

Acevedo, Orlando ;

Harper, Willie F., Jr. .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2012, 46 (02) :760-768

[5] First synthesis of separable isomeric testosterone dimers showing differential activities on prostate cancer cells [J].

Bastien, Dominic ;

Leblanc, Valerie ;

Asselin, Eric ;

Berube, Gervais .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (07) :2078-2081

[6] Characterisation of the affinity of different anabolics and synthetic hormones to the human androgen receptor, human sex hormone binding globulin and to the bovine progestin receptor [J].

Bauer, ERS ;

Daxenberger, A ;

Petri, T ;

Sauerwein, H ;

Meyer, HHD .

APMIS, 2000, 108 (12) :838-846

[7] Occurrence of androgens in sewage treatment plants influents is associated with antagonist activities on other steroid receptors [J].

Bellet, Virginie ;

Hernandez-Raquet, Guillermina ;

Dagnino, Sonia ;

Seree, Ludivine ;

Pardon, Patrick ;

Bancon-Montiny, Chrystelle ;

Fenet, Helene ;

Creusot, Nicolas ;

Ait-Aissa, Selim ;

Cavailles, Vincent ;

Budzinski, Helene ;

Antignac, Jean-Philippe ;

Balaguer, Patrick .

WATER RESEARCH, 2012, 46 (06) :1912-1922

[8] Reproductive endocrine disruption in smallmouth bass (Micropterus dolomieu) in the Potomac River basin: spatial and temporal comparisons of biological effects [J].

Blazer, Vicki S. ;

Iwanowicz, Luke R. ;

Henderson, Holly ;

Mazik, Patricia M. ;

Jenkins, Jill A. ;

Alvarez, David A. ;

Young, John A. .

ENVIRONMENTAL MONITORING AND ASSESSMENT, 2012, 184 (07) :4309-4334

[9] Pharmaceuticals and Personal Care Products in the Environment: What Are the Big Questions? [J].

Boxall, Alistair B. A. ;

Rudd, Murray A. ;

Brooks, Bryan W. ;

Caldwell, Daniel J. ;

Choi, Kyungho ;

Hickmann, Silke ;

Innes, Elizabeth ;

Ostapyk, Kim ;

Staveley, Jane P. ;

Verslycke, Tim ;

Ankley, Gerald T. ;

Beazley, Karen F. ;

Belanger, Scott E. ;

Berninger, Jason P. ;

Carriquiriborde, Pedro ;

Coors, Anja ;

DeLeo, Paul C. ;

Dyer, Scott D. ;

Ericson, Jon F. ;

Gagne, Francois ;

Giesy, John P. ;

Gouin, Todd ;

Hallstrom, Lars ;

Karlsson, Maja V. ;

Larsson, D. G. Joakim ;

Lazorchak, James M. ;

Mastrocco, Frank ;

McLaughlin, Alison ;

McMaster, Mark E. ;

Meyerhoff, Roger D. ;

Moore, Roberta ;

Parrott, Joanne L. ;

Snape, Jason R. ;

Murray-Smith, Richard ;

Servos, Mark R. ;

Sibley, Paul K. ;

Straub, Juerg Oliver ;

Szabo, Nora D. ;

Topp, Edward ;

Tetreault, Gerald R. ;

Trudeau, Vance L. ;

Van Der Kraak, Glen .

ENVIRONMENTAL HEALTH PERSPECTIVES, 2012, 120 (09) :1221-1229

[10] Heterocyclic Aromatic Hydrocarbons Show Estrogenic Activity upon Metabolization in a Recombinant Transactivation Assay [J].

Brinkmann, Markus ;

Maletz, Sibylle ;

Krauss, Martin ;

Bluhm, Kerstin ;

Schiwy, Sabrina ;

Kuckelkorn, Jochen ;

Tiehm, Andreas ;

Brack, Werner ;

Hollert, Henner .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2014, 48 (10) :5892-5901

← 1 2 3 4 5 6 7 →