Evolution of body weight parameters up to 3years after solid organ transplantation: The prospective Swiss Transplant Cohort Study

Obesity and weight gain are serious concerns after solid organ transplantation (Tx); however, no unbiased comparison regarding body weight parameter evolution across organ groups has yet been performed. Using data from the prospective nationwide Swiss Transplant Cohort Study, we compared the evolution of weight parameters up to 3years post-Tx in 1359 adult kidney (58.3%), liver (21.7%), lung (11.6%), and heart (8.4%) recipients transplanted between May 2008 and May 2012. Changes in mean weight and body mass index (BMI) category were compared to reference values from 6months post-Tx. At 3years post-Tx, compared to other organ groups, liver Tx recipients showed the greatest weight gain (mean 4.8 +/- 10.4kg), 57.4% gained >5% body weight, and they had the highest incidence of obesity (38.1%). After 3years, based on their BMI categories at 6months, normal weight and obese liver Tx patients, as well as underweight kidney, lung and heart Tx patients had the highest weight gains. Judged against international Tx patient data, the majority of our Swiss Tx recipients' experienced lower post-Tx weight gain. However, our findings show weight gain pattern differences, both within and across organ Tx groups that call for preventive measures.