The antitumor activity of a red alga polysaccharide complexes carrying 5-fluorouracil

被引：31

作者：

Wang, Xiaomei ^{[1
]}

Zhang, Zhongshan ^{[1
]}

机构：

[1] Huzhou Teachers Coll, Dept Pharmacol, Huzhou 313000, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2014年 / 69卷

关键词：

Low-molecular-weight porphyran; 5-Fu; Antitumor; TNF-ALPHA; ANTIOXIDANT ACTIVITIES; PORPHYRA-HAITANENSIS; MOLECULAR-WEIGHT; SIL-2R; GROWTH; CELLS; ACID; IL-8; 5-FU;

D O I：

10.1016/j.ijbiomac.2014.06.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Porphyran is a sulfated galactan isolated from red algae Porphyra haitanensis, and have been reported to have many kinds of biological activities such as antitumor activity. In order to provide a water-soluble macromolecule prodrug of 5-Fu showing slow release of 5-Fu and reducing side-effect, we carried out fixation of 5-Fu to porphyran at 6-position. In this study, the antitumor and immunomodulation activities of low MW porphyran carrying 5-Fu on transplanted S180 tumor mice were studied. Weight of immune organ, proliferation ratio of lymphocyte concentration of TNF-alpha and NO from the transplanted S180 tumor mice were also determined. Results indicated that the conjugate could enhance antitumor activity of 5-Fu and improve immunocompetence damaged by 5-Fu. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：542 / 545

页数：4

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