Mapping aldehydic load in vivo by positron emission tomography with [18F]NA3BF3

被引：7
作者：
Kirby, Alexia [1 ]
Suchy, Mojmir [2 ,3 ]
Brouwer, Andrea [2 ]
Shuhendler, Adam [1 ,2 ,3 ]
机构：
[1] Univ Ottawa, Dept Biol, Ottawa, ON, Canada
[2] Univ Ottawa, Dept Chem & Biomol Sci, Ottawa, ON, Canada
[3] Univ Ottawa, Inst Heart, Ottawa, ON, Canada
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 37期
基金：
加拿大自然科学与工程研究理事会; 加拿大健康研究院;
关键词：
LIPID-PEROXIDATION; COUPLING PROTEINS; HYDRAZONE; LIPOPOLYSACCHARIDE; POLYGLUTARALDEHYDE; MICROSPHERES; DEGRADATION; MECHANISMS; REAGENT; INJURY;
D O I：
10.1039/c9cc01831j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new radiotracer, [F-18]NA(3)BF(3), capable of rapid, stable, and catalyst-free complexation of aldehydes in vivo is reported. [F-18]NA(3)BF(3) was shown to bind aldehydes in live subjects using locally administered aldehyde-presenting microparticles, and was then applied to mapping aldehydic load in a mouse model of sepsis. [F-18]NA(3)BF(3) may enable the direct investigation of the chemical biology of aldehydes in living subjects, and may open avenues for the adoption of endogenous aldehydic load as an imaging biomarker of inflammatory pathology.
引用
收藏
页码：5371 / 5374
页数：4
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