Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease

被引:349
作者
Lovell, MA
Ehmann, WD
Mattson, MP
Markesbery, WR
机构
[1] UNIV KENTUCKY, SANDERS BROWN CTR AGING 101, LEXINGTON, KY 40536 USA
[2] UNIV KENTUCKY, DEPT CHEM, LEXINGTON, KY 40536 USA
[3] UNIV KENTUCKY, DEPT PATHOL & NEUROL, LEXINGTON, KY 40536 USA
[4] UNIV KENTUCKY, DEPT ANAT & NEUROBIOL, LEXINGTON, KY 40536 USA
关键词
Alzheimer's disease; oxidative stress; 4-hydroxynonenal; ventricular fluid; lipid peroxidation;
D O I
10.1016/S0197-4580(97)00108-5
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
4-Hydroxynonenal (4-HNE), an aldehyde by-product of the peroxidation of fatty acids, has been shown to have toxic properties for neurons in culture. In light of increasing evidence that oxidative stress contributes to the neurodegenerative process in Alzheimer's disease (AD), we quantified levels of free and protein-bound 4-HNE in the ventricular fluid from 19 AD subjects and 13 control subjects by high-pressure liquid chromotography and dot-blot immunoassay. Free 4-HNE levels were found to be significantly elevated in the ventricular fluid of AD subjects compared with control subjects (p = 0.0096). These results demonstrate increased lipid peroxidation in AD brain and suggest a role for 4-HNE in the neurodegenerative process. (C) 1997 Elsevier Science Inc.
引用
收藏
页码:457 / 461
页数:5
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