A Lewis acid-mediated protocol for the protection of aryl amines as their Boc-derivatives

被引：87
作者：
Bartoli, G
Bosco, M
Locatelli, M
Marcantoni, E
Massaccesi, M
Melchiorre, P
Sambri, L
机构：
[1] Dipartimento Chim Organ A Mangini, I-40136 Bologna, Italy
[2] Univ Camerino, Dipartimento Sci Chim, I-62032 Camerino, Italy
来源：
SYNLETT | 2004年 / 10期
关键词：
protection; Lewis acid; zinc perchlorate; aryl amines; Boc-derivatives;
D O I：
10.1055/s-2004-829059
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new protocol of protection of poorly reactive aryl amines and functionalized amines with Boc(2)O in the presence of Zn(ClO4)(2).6H(2)O as the catalyst is reported. The catalytic action of Zn(ClO4)(2).6H(2)O is specific for the activation of the pyrocarbonates, thus acid sensitive functionalities and stereochemical configurations of the starting materials remain unaltered in the protection process.
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收藏
页码：1794 / 1798
页数：5
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